Evidence map›Paper›PMID 38924432›Full record

ArticleScience translational medicine2024

MEK-SHP2 inhibition prevents tibial pseudarthrosis caused by

Simon Perrin, Sanela Protic, Vincent Bretegnier, Ingrid Laurendeau, Oriane Duchamp de Lageneste, Nicolas Panara, Odile Ruckebusch, Marine Luka, Cécile Masson, Théodora Maillard and 11 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science translational medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. What's New in Musculoskeletal Basic Science.The Journal of bone and joint surgery. American volume · 2025
    Article
  6. Article
  7. The Periosteum in Health and Disease.Current osteoporosis reports · 2025
    Review
  8. Molecular Basis of Fracture Pseudarthrosis Associated with Neurofibromatosis Type 1.Journal of the Pediatric Orthopaedic Society of North America · 2025
    Review
  9. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

21 authors.

Simon PerrinUniversité Paris Est Creteil, INSERM, IMRB, 94000 Creteil, France.ORCID 0000-0003-3598-2617
Sanela ProticUniversité Paris Est Creteil, INSERM, IMRB, 94000 Creteil, France.
Vincent BretegnierUniversité Paris Est Creteil, INSERM, IMRB, 94000 Creteil, France.
Ingrid LaurendeauINSERM UMR S1016, Institut Cochin, Université Paris Cité, 75014 Paris, France.ORCID 0009-0003-5437-0015
Oriane Duchamp de LagenesteUniversité Paris Est Creteil, INSERM, IMRB, 94000 Creteil, France.
Nicolas PanaraINSERM UMR S1016, Institut Cochin, Université Paris Cité, 75014 Paris, France.ORCID 0009-0003-4383-5593
Odile RuckebuschUniversité Paris Est Creteil, INSERM, IMRB, Plateforme de Cytométrie en flux, 94000 Creteil, France.ORCID 0009-0007-2289-6257
Marine LukaParis Cité University, Imagine Institute, Laboratory of Inflammatory Responses and Transcriptomic Networks in Diseases, Atip-Avenir Team, INSERM UMR 1163, 75015 Paris, France.
Cécile MassonBioinformatics Core Facility, Institut Imagine-Structure Fédérative de Recherche Necker, INSERM U1163, 75015 Paris, France.ORCID 0000-0001-7870-7821
Théodora MaillardService de Médecine Génomique des Maladies de Système et d'Organe, Hôpital Cochin, DMU BioPhyGen, Assistance Publique-Hôpitaux de Paris, AP-HP, Centre-Université Paris Cité, F-75014 Paris, France.ORCID 0009-0002-7812-0320
Fanny CoulpierUniversité Paris Est Creteil, INSERM, IMRB, 94000 Creteil, France.
Stéphanie PannierDepartment of Pediatric Orthopedic Surgery and Traumatology, Necker-Enfants Malades Hospital, AP-HP, Paris Cité University, 75015 Paris, France.ORCID 0000-0002-5581-4699
Philippe WicartDepartment of Pediatric Orthopedic Surgery and Traumatology, Necker-Enfants Malades Hospital, AP-HP, Paris Cité University, 75015 Paris, France.
Smail Hadj-RabiaDepartment of Dermatology, Reference Center for Rare Skin Diseases (MAGEC), Imagine Institute, Necker-Enfants Malades Hospital, AP-HP, Paris Cité University, 75015 Paris, France.
Katarzyna J RadomskaUniversité Paris Est Creteil, INSERM, IMRB, 94000 Creteil, France.ORCID 0000-0001-8243-0669
Mohammed ZarhrateINSERM US24/CNRS UAR3633, Paris Cité University, 75015 Paris, France.
Mickael MénagerParis Cité University, Imagine Institute, Laboratory of Inflammatory Responses and Transcriptomic Networks in Diseases, Atip-Avenir Team, INSERM UMR 1163, 75015 Paris, France.
Dominique VidaudINSERM UMR S1016, Institut Cochin, Université Paris Cité, 75014 Paris, France.ORCID 0009-0004-4777-1387
Piotr TopilkoUniversité Paris Est Creteil, INSERM, IMRB, 94000 Creteil, France.ORCID 0000-0001-7381-6770
Béatrice ParfaitINSERM UMR S1016, Institut Cochin, Université Paris Cité, 75014 Paris, France.ORCID 0000-0002-2964-8666
Céline ColnotUniversité Paris Est Creteil, INSERM, IMRB, 94000 Creteil, France.ORCID 0000-0001-8423-8718

Funding

Cell Transitions during Bone Fracture HealingR01AR081671 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Ralph S Marcucio · 2023 to 2026
$2.1M
NIAMS NIH HHS R01 AR081671
6 · The paper itself

Abstract

Congenital pseudarthrosis of the tibia (CPT) is a severe pathology marked by spontaneous bone fractures that fail to heal, leading to fibrous nonunion. Half of patients with CPT are affected by the multisystemic genetic disorder neurofibromatosis type 1 (NF1) caused by mutations in the

Indexed as

Mice, KnockoutNeurofibromin 1Protein Tyrosine Phosphatase, Non-Receptor Type 11PseudarthrosisSchwann CellsAnimalsCell DifferentiationFemaleFibrosisHumansMaleMiceMitogen-Activated Protein Kinase KinasesNeurofibromatosis 1Stem CellsTibiaMitogen-Activated Protein Kinase KinasesNeurofibromin 1NF1 protein, humanNf1 protein, mouseProtein Tyrosine Phosphatase, Non-Receptor Type 11PTPN11 protein, humanPtpn11 protein, mouse

Identifiers

PMID38924432
PMCPMC12093263

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.