Evidence map›Paper›PMID 38924391›Full record

ArticleACS nano2024

Developing and Investigating a Nanovibration Intervention for the Prevention/Reversal of Bone Loss Following Spinal Cord Injury.

Jonathan A Williams, Paul Campsie, Richard Gibson, Olivia Johnson-Love, Anna Werner, Mark Sprott, Ryan Meechan, Carmen Huesa, James F C Windmill, Mariel Purcell and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS nano, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Jonathan A WilliamsCentre for the Cellular Microenvironment, Department of Biomedical Engineering, Wolfson Centre, University of Strathclyde, Glasgow G4 0NW, U.K.ORCID 0000-0002-9828-4886
Paul CampsieCentre for the Cellular Microenvironment, Department of Biomedical Engineering, Wolfson Centre, University of Strathclyde, Glasgow G4 0NW, U.K.
Richard GibsonCentre for the Cellular Microenvironment, Department of Biomedical Engineering, Wolfson Centre, University of Strathclyde, Glasgow G4 0NW, U.K.
Olivia Johnson-LoveCentre for the Cellular Microenvironment, Department of Biomedical Engineering, Wolfson Centre, University of Strathclyde, Glasgow G4 0NW, U.K.
Anna WernerCentre for the Cellular Microenvironment, Department of Biomedical Engineering, Wolfson Centre, University of Strathclyde, Glasgow G4 0NW, U.K.
Mark SprottCentre for the Cellular Microenvironment, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, U.K.
Ryan MeechanCentre for the Cellular Microenvironment, Department of Biomedical Engineering, Wolfson Centre, University of Strathclyde, Glasgow G4 0NW, U.K.
Carmen HuesaInstitute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, U.K.
James F C WindmillDepartment of Electronic and Electrical Engineering, Royal College Building, University of Strathclyde, Glasgow G1 1XW, U.K.ORCID 0000-0003-4878-349X
Mariel PurcellScottish Centre for Innovation in Spinal Cord Injury, Queen Elizabeth National Spinal Injuries Unit, Queen Elizabeth University Hospital, Glasgow G51 4TF, U.K.
Sylvie CoupaudCentre for the Cellular Microenvironment, Department of Biomedical Engineering, Wolfson Centre, University of Strathclyde, Glasgow G4 0NW, U.K.
Matthew J DalbyCentre for the Cellular Microenvironment, Institute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, U.K.ORCID 0000-0002-0528-3359
Peter ChildsCentre for the Cellular Microenvironment, Department of Biomedical Engineering, Wolfson Centre, University of Strathclyde, Glasgow G4 0NW, U.K.
John S RiddellSchool of Psychology and Neuroscience, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, U.K.
Stuart ReidCentre for the Cellular Microenvironment, Department of Biomedical Engineering, Wolfson Centre, University of Strathclyde, Glasgow G4 0NW, U.K.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteoporosis disrupts the fine-tuned balance between bone formation and resorption, leading to reductions in bone quantity and quality and ultimately increasing fracture risk. Prevention and treatment of osteoporotic fractures is essential for reductions in mortality, morbidity, and the economic burden, particularly considering the aging global population. Extreme bone loss that mimics time-accelerated osteoporosis develops in the paralyzed limbs following complete spinal cord injury (SCI). In vitro nanoscale vibration (1 kHz, 30 or 90 nm amplitude) has been shown to drive differentiation of mesenchymal stem cells toward osteoblast-like phenotypes, enhancing osteogenesis and inhibiting osteoclastogenesis simultaneously. Here, we develop and characterize a wearable device designed to deliver and monitor continuous nanoamplitude vibration to the hindlimb long bones of rats with complete SCI. We investigate whether a clinically feasible dose of nanovibration (two 2 h/day, 5 days/week for 6 weeks) is effective at reversing the established SCI-induced osteoporosis. Laser interferometry and finite element analysis confirmed transmission of nanovibration into the bone, and microcomputed tomography and serum bone formation and resorption markers assessed effectiveness. The intervention did not reverse SCI-induced osteoporosis. However, serum analysis indicated an elevated concentration of the bone formation marker procollagen type 1

Indexed as

OsteoporosisSpinal Cord InjuriesVibrationAnimalsFemaleNanotechnologyOsteogenesisRatsRats, Sprague-DawleyWearable Electronic DevicesX-Ray Microtomographybiophysical stimulationmechanotransductionmesenchymal stem cellsmicroCTosteogenesisosteoporosisvibration

Identifiers

PMID38924391
PMCPMC11238619

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.