Evidence map›Paper›PMID 38924235›Full record

ArticleHuman brain mapping2024

Surface-based morphometry of the corpus callosum in young children of ages 1-5.

Niharika Gajawelli, Athelia Paulli, Sean Deoni, Natacha Paquette, Danielle Darakjian, Carlos Salazar, Douglas Dean, Jonathan O'Muircheartaigh, Marvin D Nelson, Yalin Wang and 1 more

Abstract read
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In one paragraph

Article in Human brain mapping, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Niharika GajawelliCIBORG Lab, Department of Radiology, Children's Hospital Los Angeles, Los Angeles, California, USA.
Athelia PaulliCIBORG Lab, Department of Radiology, Children's Hospital Los Angeles, Los Angeles, California, USA.ORCID 0000-0002-4775-493X
Sean DeoniDepartment of Pediatrics, Warren Alpert Medical School at Brown University, Providence, Rhode Island, USA.
Natacha PaquetteCIBORG Lab, Department of Radiology, Children's Hospital Los Angeles, Los Angeles, California, USA.
Danielle DarakjianCIBORG Lab, Department of Radiology, Children's Hospital Los Angeles, Los Angeles, California, USA.
Carlos SalazarCIBORG Lab, Department of Radiology, Children's Hospital Los Angeles, Los Angeles, California, USA.
Douglas DeanWaisman Laboratory for Brain Imaging and Behavior, University of Wisconsin Madison, Madison, Wisconsin, USA.
Jonathan O'MuircheartaighDepartment of Neuroimaging, King's College London, London, UK.ORCID 0000-0002-8033-6959
Marvin D NelsonDepartment of Pediatrics, University of Southern California, Los Angeles, California, USA.
Yalin WangDepartment of Computer Science, Arizona State University, Tempe, Arizona, USA.ORCID 0000-0002-6241-735X
Natasha LeporeCIBORG Lab, Department of Radiology, Children's Hospital Los Angeles, Los Angeles, California, USA.

Funding

Waisman Intellectual and Developmental Disabilities Research Center Down Syndrome RegistryU54HD090256 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI MESSING, ALBEE · 2016 to 2020
$6.0M
Early joint cranial and brain development from fetal and pediatric imagingR01DE030286 · NIDCR · CHILDREN'S HOSPITAL OF LOS ANGELES · PI LEPORE, NATASHA, LINGURARU, MARIUS GEORGE · 2021 to 2025
$3.5M
Predicting the early childhood outcomes of preterm brain shape abnormalitiesR01EB025032 · NIBIB · CHILDREN'S HOSPITAL OF LOS ANGELES · PI LEPORE, NATASHA · 2017 to 2020
$2.6M
Eunice Kennedy Shriver National Institute of Child Health and Human Development U54HD090256Gates Foundation INV-047887Medical Research Council Center for Neurodevelopmental Disorders, King's College Londo MR/N026063/1NIBIB NIH HHS R01 EB025032NIBIB NIH HHS R01EB025032NICHD NIH HHS U54 HD090256NIDCR NIH HHS R01 DE030286NIDCR NIH HHS R01DE030286NIMH NIH HHS R00MH11056Saban Research Institute 000013228Wellcome TrustWellcome Trust and the Royal Society 206675/Z/17/Z
6 · The paper itself

Abstract

The corpus callosum (CC) is a large white matter fiber bundle in the brain and is involved in various cognitive, sensory, and motor processes. While implicated in various developmental and psychiatric disorders, much is yet to be uncovered about the normal development of this structure, especially in young children. Additionally, while sexual dimorphism has been reported in prior literature, observations have not necessarily been consistent. In this study, we use morphometric measures including surface tensor-based morphometry (TBM) to investigate local changes in the shape of the CC in children between the ages of 12 and 60 months, in intervals of 12 months. We also analyze sex differences in each of these age groups. We observed larger significant clusters in the earlier ages between 12 v 24 m and between 48 v 60 m and localized differences in the anterior region of the body of the CC. Sex differences were most pronounced in the 12 m group. This study adds to the growing literature of work aiming to understand the developing brain and emphasizes the utility of surface TBM as a useful tool for analyzing regional differences in neuroanatomical morphometry.

Indexed as

Corpus CallosumSex CharacteristicsChild, PreschoolDiffusion Tensor ImagingFemaleHumansImage Processing, Computer-AssistedInfantMagnetic Resonance ImagingMale

Identifiers

PMID38924235
PMCPMC11199824

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.