Evidence map›Paper›PMID 38924105›Full record

ArticlePsychophysiology2024

Task-based default mode network connectivity predicts cognitive impairment and negative symptoms in first-episode schizophrenia.

Anika Guha, Tzvetan Popov, Morgan E Bartholomew, Alexandra C Reed, Caroline K Diehl, Kenneth L Subotnik, Joseph Ventura, Keith H Nuechterlein, Gregory A Miller, Cindy M Yee

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychophysiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Can auditory processing dysfunction indicate early cognitive decline?Alzheimer's & dementia (Amsterdam, Netherlands)
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Anika GuhaDepartment of Psychology, University of California, Los Angeles, Los Angeles, California, USA.ORCID 0000-0002-4576-5037
Tzvetan PopovDepartment of Psychology, Methods of Plasticity Research, University of Zurich, Zurich, Switzerland.
Morgan E BartholomewDepartment of Psychology, University of California, Los Angeles, Los Angeles, California, USA.
Alexandra C ReedDepartment of Psychology, University of California, Los Angeles, Los Angeles, California, USA.
Caroline K DiehlDepartment of Psychology, University of California, Los Angeles, Los Angeles, California, USA.
Kenneth L SubotnikDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, California, USA.
Joseph VenturaDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, California, USA.
Keith H NuechterleinDepartment of Psychology, University of California, Los Angeles, Los Angeles, California, USA.
Gregory A MillerDepartment of Psychology, University of California, Los Angeles, Los Angeles, California, USA.
Cindy M YeeDepartment of Psychology, University of California, Los Angeles, Los Angeles, California, USA.

Funding

Development of Psychopathology, Psychobiology, & BehaviorT32MH015442 · NIMH · UNIVERSITY OF COLORADO DENVER · PI JASON R TREGELLAS · 1985 to 2026
$10.2M
Enhancing Cognitive Training Through Exercise Following a First Schizophrenia EpisodeR01MH110544 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI NUECHTERLEIN, KEITH H · 2016 to 2022
$7.3M
Improving Cognition Through Telehealth Aerobic Exercise and Cognitive Training After a First Schizophrenia EpisodeR01MH130848 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KEITH H NUECHTERLEIN · 2023 to 2026
$4.9M
Identifying neural mechanisms of aberrant inhibitory processing and salience in patients with schizophreniaF31MH124421 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GUHA, ANIKA MAYA · 2021 to 2021
$25k
NIMH NIH HHS F31 MH124421NIMH NIH HHS F31 MH124421-01NIMH NIH HHS R01 MH110544NIMH NIH HHS R01 MH110544-S1NIMH NIH HHS R01 MH130848NIMH NIH HHS T32 MH015442
6 · The paper itself

Abstract

Individuals diagnosed with schizophrenia (SZ) demonstrate difficulty distinguishing between internally and externally generated stimuli. These aberrations in "source monitoring" have been theorized as contributing to symptoms of the disorder, including hallucinations and delusions. Altered connectivity within the default mode network (DMN) of the brain has been proposed as a mechanism through which discrimination between self-generated and externally generated events is disrupted. Source monitoring abnormalities in SZ have additionally been linked to impairments in selective attention and inhibitory processing, which are reliably observed via the N100 component of the event-related brain potential elicited during an auditory paired-stimulus paradigm. Given overlapping constructs associated with DMN connectivity and N100 in SZ, the present investigation evaluated relationships between these measures of disorder-related dysfunction and sought to clarify the nature of task-based DMN function in SZ. DMN connectivity and N100 measures were assessed using EEG recorded from SZ during their first episode of illness (N = 52) and demographically matched healthy comparison participants (N = 25). SZ demonstrated less evoked theta-band connectivity within DMN following presentation of pairs of identical auditory stimuli than HC. Greater DMN connectivity among SZ was associated with better performance on measures of sustained attention (p = .03) and working memory (p = .09), as well as lower severity of negative symptoms, though it was not predictive of N100 measures. Together, present findings provide EEG evidence of lower task-based connectivity among first-episode SZ, reflecting disruptions of DMN functions that support cognitive processes. Attentional processes captured by N100 appear to be supported by different neural mechanisms.

Indexed as

Cognitive DysfunctionDefault Mode NetworkElectroencephalographySchizophreniaAdultAttentionEvoked PotentialsFemaleHumansMaleNerve NetSchizophrenic PsychologyYoung Adultattentionconnectivity/networksEEGschizophrenia

Identifiers

PMID38924105
PMCPMC11473237

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.