Evidence map›Paper›PMID 38924074›Full record

ArticleActa obstetricia et gynecologica Scandinavica2024

Physical activity and circulating inflammatory markers and cytokines during pregnancy: A population-based cohort study.

Poshmaal Dhar, Luba Sominsky, Martin O'Hely, Samantha Dawson, Fiona Collier, Mimi L K Tang, Toby Mansell, David Burgner, Craig Smith, Natalie Hyde and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta obstetricia et gynecologica Scandinavica, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Exercise benefits yourself and your offspring: a mini-review.Frontiers in cell and developmental biology · 2025
    Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Poshmaal DharInstitute for Mental and Physical Health and Clinical Translation (IMPACT), School of Medicine, Deakin University, Geelong, Victoria, Australia.ORCID 0000-0002-2842-007X
Luba SominskyInstitute for Mental and Physical Health and Clinical Translation (IMPACT), School of Medicine, Deakin University, Geelong, Victoria, Australia.
Martin O'HelyInstitute for Mental and Physical Health and Clinical Translation (IMPACT), School of Medicine, Deakin University, Geelong, Victoria, Australia.ORCID 0000-0002-0212-1207
Samantha DawsonInstitute for Mental and Physical Health and Clinical Translation (IMPACT), School of Medicine, Deakin University, Geelong, Victoria, Australia.
Fiona CollierInstitute for Mental and Physical Health and Clinical Translation (IMPACT), School of Medicine, Deakin University, Geelong, Victoria, Australia.
Mimi L K TangMurdoch Children's Research Institute, Royal Children's Hospital, Parkville, Victoria, Australia.
Toby MansellMurdoch Children's Research Institute, Royal Children's Hospital, Parkville, Victoria, Australia.
David BurgnerMurdoch Children's Research Institute, Royal Children's Hospital, Parkville, Victoria, Australia.
Craig SmithInstitute for Mental and Physical Health and Clinical Translation (IMPACT), School of Medicine, Deakin University, Geelong, Victoria, Australia.
Natalie HydeInstitute for Mental and Physical Health and Clinical Translation (IMPACT), School of Medicine, Deakin University, Geelong, Victoria, Australia.
Katherine DowningInstitute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Deakin University, Geelong, Victoria, Australia.
Kylie D HeskethInstitute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Deakin University, Geelong, Victoria, Australia.
Anne-Louise PonsonbyMurdoch Children's Research Institute, Royal Children's Hospital, Parkville, Victoria, Australia.
Peter VuillerminInstitute for Mental and Physical Health and Clinical Translation (IMPACT), School of Medicine, Deakin University, Geelong, Victoria, Australia.
Barwon Infant Study Investigator Group

Funding

Barwon HealthCotton On FoundationCreativeForceGeelong Medical and Hospital Benefits AssociationIlhan Food Allergy FoundationJack Brockhoff FoundationMinderoo FoundationMurdoch Children's Research InstituteNational Health and Medical Research Council of AustraliaOur Women Our Children's Fund Raising Committee Barwon HealthPercy Baxter Charitable TrustPerpetual TrusteesRotary Club of GeelongScobie & Claire McKinnon TrustShane O'Brien Memorial Asthma FoundationShepherd FoundationVanguard Investments Australia LtdVictorian Government's Operational Infrastructure Support Program
6 · The paper itself

Abstract

introductionPhysical activity (PA) during pregnancy has numerous benefits, which may be mediated via effects on the immune system. However, supportive evidence is inconsistent and is mainly from studies in high-risk groups. We estimated the effect of PA during pregnancy on systemic inflammatory markers and cytokines in mothers recruited in the Barwon infant study. MATERIAL AND

methodsThe Barwon infant study is a prebirth cohort of 1064 mothers recruited in the Barwon Region of Victoria, Australia. Participants reported their previous week's PA at their 28-week antenatal appointment using the International PA Questionnaire. Women were grouped into low, moderate, and high PA categories based on daily duration and weekly frequency of walking, moderate- or vigorous-intensity PA. Women reporting moderate levels of PA, consistent with current recommendations, served as the comparison group. Markers of systemic inflammation, high-sensitivity C-reactive protein (hsCRP), glycoprotein acetyls (GlycA), and 17 cytokines were measured at 28 weeks gestation and log transformed as appropriate. Regression analyses adjusted for maternal smoking, gestational diabetes mellitus, prepregnancy BMI, and household size were performed.

resultsCompared to women in the moderate group (n = 371, 42%), women reporting low PA (n = 436, 50%) had 10.1% higher hsCRP (95% CI (3.7% to 16.6%), p < 0.01) while women in high PA (n = 76, 9%) had a 14% higher hsCRP (95% CI (3.1% to 24.8%), p = 0.01). Women in the high PA category had higher interleukin (IL)-4 (q = 0.03) and IL-9 (q = 0.03) levels compared to those in moderate category. Each vigorous MET minute/week was associated with lower GlycA (β = -0.004, 95% CI (-0.044 to 0.035); p = 0.03).

conclusionsLow and high PA are each associated with higher hsCRP than moderate PA, suggesting that undertaking the recommended moderate PA during pregnancy decreases systemic inflammation. High PA affects T cell-associated cytokines during pregnancy. Evidence from our study suggests that PA can modulate the immune responses during pregnancy. Studies are now required to assess whether PA during pregnancy impacts maternal and infant clinical outcomes by modifying inflammatory responses.

Indexed as

BiomarkersCytokinesAdultCohort StudiesC-Reactive ProteinExerciseFemaleHumansInflammationMotor ActivityPregnancyVictoriaBiomarkersC-Reactive ProteinCytokineschemokinescytokinesgestationGlycAhsCRPIL‐4IL‐9inflammationphysical activitypregnancy

Identifiers

PMID38924074
PMCPMC11324931

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.