ArticlePloS one2024
Serum copper and obesity among healthy adults in the National Health and Nutrition Examination Survey.
Article in PloS one, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Copper dysregulation in cardiometabolic disease: copper deficiency versus cuproptosis.Apoptosis : an international journal on programmed cell death · 2026Review
- Association Between Dietary Copper Intake and Incident Metabolic Syndrome in Chinese Adults: A Discrete-Time Hazard Model Analysis.Nutrients · 2026Article
- Prenatal exposure to essential and toxic elements in relation to infant growth trajectories.Environmental health : a global access science source · 2026Article
- Associations of Metal Mixtures During Early Pregnancy With Midlife Obesity and Body Composition: A Prospective Study.Obesity (Silver Spring, Md.) · 2025Article
- Association of metformin treatment with changes in metal dynamics in individuals with type 2 diabetes.BMJ open diabetes research & care · 2025Article
- Copper and hepatic lipid dysregulation: Mechanisms and implications.World journal of hepatology · 2025Review
- Iron status and dietary iron intake in relation to overweight/obesity in U.S. adults: a nationwide population-based study.Frontiers in nutrition · 2025Article
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCopper (Cu) homeostasis are important processes in the cause of metabolic diseases, but the association between Cu and obesity remains unclear.
methodsParticipants were drawn from the 2011-2016 National Health and Nutrition Examination Survey (NHANES). Weighted logistic regression assessed the associations of serum Cu concentrations (tertiles) with obesity and central obesity in individuals without comorbidities. Obesity was defined as a BMI ≥30.0 kg/m2, and central obesity was defined as a waist circumference ≥80 cm for women and ≥95 cm for men.
resultsThis cross-sectional study included 1,665 adults without comorbidities, representing 24,744,034 people (mean age 35.1 years, 48.5% female). High serum Cu levels (tertile 3: ≥19.19 μmol/L) were associated with higher odds of obesity (adjusted odds ratio [OR]: 4.48, 95% CI[confidence interval]: 2.44-8.32) and central obesity (OR: 2.36, 95% CI: 1.19-4.66) compared to low serum Cu levels (tertile 1: ≤15.64 μmol/L). The dose-response curve showed a nonlinear association between Cu levels and obesity (P-nonlinear = 0.02) and a linear association with central obesity (P-nonlinear = 0.21).
conclusionThis study suggests that higher serum Cu levels are associated with increased odds of obesity in healthy American adults.
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