ArticleJournal of cachexia, sarcopenia and muscle2024
The association between dynamic changes in vitamin D and frailty alterations: A prospective analysis of UK Biobank participants.
Article in Journal of cachexia, sarcopenia and muscle, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Mapping Research Trends in Frailty and Nutrition: A Combined Bibliometric and Structured Review (2000-2024).Nutrients · 2025Pooled it
- Frailty and risk of common chronic diseases among cancer survivors: a prospective cohort study.Journal of cancer survivorship : research and practice · 2026Article
- The Double-Deficient Older Inpatient: Vitamin D and Vitamin B12 Co-Deficiency Identifies the Greatest Cognitive and Affective Burden.Nutrients · 2026Article
- Frailty for cardiovascular risk stratification in CKM syndrome stages 0-3: a UK Biobank prospective cohort study.Frontiers in cardiovascular medicine · 2026Article
- The Biological Mechanisms of Frailty: Focusing on Cellular Senescence.European cardiology · 2026Review
- Early-life exposure to tobacco smoke increase risk of frailty in adulthood: evidence from a large prospective cohort study.Journal of translational medicine · 2025Article
- Association Between Stress Hyperglycemia Ratio and Parkinson's Disease Across Different Glucose Metabolism Statuses-A Prospective Study From UK Biobank.European journal of neurology · 2025Article
- Association between the coexistence of chronic kidney disease and sarcopenia with cardiovascular disease and mortality.Aging clinical and experimental research · 2025Article
- Association between physical activity and frailty transitions in middle-aged and older adults: a nationwide longitudinal study.The international journal of behavioral nutrition and physical activity · 2025Article
- Triglyceride-glucose index, renal function, sleep duration, and myocardial infarction: a UK biobank cohort study.Frontiers in nutrition · 2025Article
- Cholecystectomy and the risk of osteoporosis and fractures: a systematic review and meta-analysis.Therapeutic advances in musculoskeletal disease · 2025Article
- Development and validation of a biological frailty score based on CRP, haemoglobin, albumin and vitamin D within an electronic health record database in France: a cross-sectional study.BMJ public health · 2025Article
- The association between dynamic changes in vitamin D and frailty alterations: A prospective analysis of UK Biobank participants.Journal of cachexia, sarcopenia and muscle · 2024Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
backgroundFrailty is a common geriatric syndrome associated with reduced reserves and increased vulnerability to stressors among older adults. Vitamin D deficiency has been implicated in frailty, as it is essential for maintaining musculoskeletal functions. The relationship between dynamic changes in vitamin D levels and frailty over time has not been extensively studied.
methodsThis study utilized data from the UK Biobank. Baseline and longitudinal changes in vitamin D levels were measured. Frailty status was assessed using both the frailty phenotype and frailty index approaches and classified as robust, pre-frail, or frail. Changes in frailty status were assessed by frailty phenotype at baseline (2006-2010) and the follow-up (2012-2013). Mixed effect model was performed to examine the association between vitamin D levels and frailty status. Using multistate transition models, we assessed the impact of increasing vitamin D levels on the probabilities of transitioning between robust, pre-frail, and frail states.
resultsBased on the frailty phenotype, 287 926 individuals (64.8%) were identified as having various degrees of frailty (median age 58.00 [51.00, 64.00] years, 55.9% females). Using the frailty index approach, 250 566 individuals (56%) were found to have different levels of frailty (median age 59.00 [51.00, 64.00] years, 55.3% females). Baseline vitamin D levels were found to be significantly associated with frailty status (frailty phenotype: OR
conclusionsThis study highlights the importance of vitamin D in the context of frailty. Low vitamin D levels are associated with increased frailty risk, while increasing vitamin D levels may contribute to improving frailty status. Recognizing the relationship between vitamin D levels and frailty can inform personalized management and early interventions for frail individuals. Further research is needed to explore the potential effects of vitamin D interventions on frailty and deepen our understanding of the biological connections between vitamin D and frailty.
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