Evidence map›Paper›PMID 38923603›Full record

ArticleExperimental physiology2024

DYNamic Assessment of Multi-Organ level dysfunction in patients recovering from COVID-19: DYNAMO COVID-19.

Ayushman Gupta, Rosemary Nicholas, Jordan J McGing, Aline V Nixon, Joanne E Mallinson, Tricia M McKeever, Christopher R Bradley, Mathew Piasecki, Eleanor F Cox, James Bonnington and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Ayushman GuptaNIHR Nottingham Biomedical Research Centre, Nottingham, UK.ORCID 0000-0002-2345-545X
Rosemary NicholasSir Peter Mansfield Imaging Centre, School of Physics & Astronomy, University of Nottingham, Nottingham, UK.
Jordan J McGingDavid Greenfield Human Physiology Unit, School of Life Sciences, University of Nottingham, Nottingham, UK.
Aline V NixonDavid Greenfield Human Physiology Unit, School of Life Sciences, University of Nottingham, Nottingham, UK.
Joanne E MallinsonDavid Greenfield Human Physiology Unit, School of Life Sciences, University of Nottingham, Nottingham, UK.
Tricia M McKeeverNIHR Nottingham Biomedical Research Centre, Nottingham, UK.
Christopher R BradleySir Peter Mansfield Imaging Centre, School of Physics & Astronomy, University of Nottingham, Nottingham, UK.
Mathew PiaseckiNIHR Nottingham Biomedical Research Centre, Nottingham, UK.ORCID 0000-0002-7804-4631
Eleanor F CoxSir Peter Mansfield Imaging Centre, School of Physics & Astronomy, University of Nottingham, Nottingham, UK.
James BonningtonNottingham University Hospitals NHS Trust, Nottingham, UK.
Janet M LordMRC-Versus Arthritis Centre for Musculoskeletal Ageing Research, University of Birmingham, Birmingham, UK.
Christopher E BrightlingNIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK.
Rachael A EvansNIHR Leicester Biomedical Research Centre, University of Leicester, Leicester, UK.
Ian P HallNIHR Nottingham Biomedical Research Centre, Nottingham, UK.
Susan T FrancisNIHR Nottingham Biomedical Research Centre, Nottingham, UK.
Paul L GreenhaffNIHR Nottingham Biomedical Research Centre, Nottingham, UK.
Charlotte E BoltonNIHR Nottingham Biomedical Research Centre, Nottingham, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We evaluated the impacts of COVID-19 on multi-organ and metabolic function in patients following severe hospitalised infection compared to controls. Patients (n = 21) without previous diabetes, cardiovascular or cerebrovascular disease were recruited 5-7 months post-discharge alongside controls (n = 10) with similar age, sex and body mass. Perceived fatigue was estimated (Fatigue Severity Scale) and the following were conducted: oral glucose tolerance (OGTT) alongside whole-body fuel oxidation, validated magnetic resonance imaging and spectroscopy during resting and supine controlled exercise, dual-energy X-ray absorptiometry, short physical performance battery (SPPB), intra-muscular electromyography, quadriceps strength and fatigability, and daily step-count. There was a greater insulin response (incremental area under the curve, median (inter-quartile range)) during the OGTT in patients [18,289 (12,497-27,448) mIU/min/L] versus controls [8655 (7948-11,040) mIU/min/L], P < 0.001. Blood glucose response and fasting and post-prandial fuel oxidation rates were not different. This greater insulin resistance was not explained by differences in systemic inflammation or whole-body/regional adiposity, but step-count (P = 0.07) and SPPB scores (P = 0.004) were lower in patients. Liver volume was 28% greater in patients than controls, and fat fraction adjusted liver T

Indexed as

COVID-19Insulin ResistanceAdultAgedBlood GlucoseFatigueFemaleGlucose Tolerance TestHumansMaleMiddle AgedMuscle, SkeletalMuscle StrengthSARS-CoV-2Blood GlucoseCOVID‐19pathophysiologypost‐acute COVID‐19 syndromerecovery

Identifiers

PMID38923603
PMCPMC11291868

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.