ArticleCell reports2024
Sensation and expectation are embedded in mouse motor cortical activity.
Article in Cell reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Contextual gating of whisker-evoked responses by frontal cortex supports flexible decision making.Nature communications · 2026Article
- Perirhinal input to auditory cortex supports memory-guided sensory perception.Science advances · 2026Article
- Desegregation of neuronal predictive processing.Nature communications · 2026Article
- Widefield cortical activity and functional connectivity during motorized locomotion.Communications biology · 2026Article
- Interactions between motor cortical forelimb regions and their influence on muscles reorganize across behaviors.Nature communications · 2025Article
- Suppressing Sensation during Action across Species and Sensory Modalities: Predictive and Nonpredictive Mechanisms of Sensory Modulation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Review
- Cerebellar circuit computations for predictive motor control.Nature reviews. Neuroscience · 2025Review
- A sensory-motor theory of the neocortex.Nature neuroscience · 2024Review
- Learning within a sensory-motor circuit links action to expected outcome.bioRxiv : the preprint server for biology · 2024Article
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2 authors.
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Abstract
During behavior, the motor cortex sends copies of motor-related signals to sensory cortices. Here, we combine closed-loop behavior with large-scale physiology, projection-pattern-specific recordings, and circuit perturbations to show that neurons in mouse secondary motor cortex (M2) encode sensation and are influenced by expectation. When a movement unexpectedly produces a sound, M2 becomes dominated by sound-evoked activity. Sound responses in M2 are inherited partially from the auditory cortex and are routed back to the auditory cortex, providing a path for the reciprocal exchange of sensory-motor information during behavior. When the acoustic consequences of a movement become predictable, M2 responses to self-generated sounds are selectively gated off. These changes in single-cell responses are reflected in population dynamics, which are influenced by both sensation and expectation. Together, these findings reveal the embedding of sensory and expectation signals in motor cortical activity.
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