Evidence map›Paper›PMID 38923374›Full record

ArticleJournal of cosmetic dermatology2024

Correlation between depression scores and serum NF-ĸB/NLRP3 axis, biotinidase, and HMGB1 after treatment with isotretinoin in patients with acne vulgaris.

Ammena Y Binsaleh, Lahin Saad Ali, Mostafa M Bahaa, Thanaa A Elmasry, Walaa A Negm, Amir O Hamouda, Muhammed M Salahuddin, Eman Wahsh, Marwa Ahmed El-Samongy, Nawal Alsubaie and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cosmetic dermatology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Involvement of role of HMGB1-NLRP3 pathway in systemic disorders.Frontiers in cell and developmental biology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ammena Y BinsalehDepartment of Pharmacy Practice, College of Pharmacy, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia.
Lahin Saad AliDepartment of Basic Medical Science, Faculty of Dentistry, Al-Ahliyya Amman University, Amman, Jordan.
Mostafa M BahaaPharmacy Practice Department, Faculty of Pharmacy, Horus University, New Damietta, Egypt.ORCID https://orcid.org/0000-0003-3332-4573
Thanaa A ElmasryPharmacology and Toxicology Department, Faculty of Pharmacy, Tanta University, Tanta, Al-Gharbia, Egypt.
Walaa A NegmPharmacognosy Department, Faculty of Pharmacy, Tanta University, Tanta, Al-Gharbia, Egypt.
Amir O HamoudaDepartment of Biochemistry and Pharmacology, Faculty of Pharmacy, Horus University, New Damietta, Egypt.
Muhammed M SalahuddinDepartment of Biochemistry and Pharmacology, Faculty of Pharmacy, Horus University, New Damietta, Egypt.
Eman WahshPharmacology and Toxicology Department, Faculty of Pharmacy, Sinai University, Arish, Egypt.
Marwa Ahmed El-SamongyDermatology Department, Faculty of Medicine, Tanta University, Tanta, Al-Gharbia, Egypt.
Nawal AlsubaieDepartment of Pharmacy Practice, College of Pharmacy, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia.
Eman El-KhateebClinical Pharmacy Department, Faculty of Pharmacy, Tanta University, Tanta, Al-Gharbia, Egypt.ORCID https://orcid.org/0000-0002-8365-6528
Mohamed YasserDepartment of Pharmaceutics, Faculty of Pharmacy, Port Said University, Port Said, Egypt.
Nashwa EltantawyPharmacy Practice Department, Faculty of Pharmacy, Heliopolis University, Cairo 11757, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAcne vulgaris (AV) is an inflammatory skin disorder leading to scars and discomfort, its intensity has major psychological consequences such as depression.

aimTo investigate the effect of isotretinoin (ISO) on NF-κB/NLRP3, biotinidase, and HMGB and correlation with depression. PATIENTS AND

methodsThis was a case-control study that involved two groups. Group 1 is 20 healthy control, and group 2 is 20 patients diagnosed with AV according to Global Acne Grading System (GAGS) and received 20 mg ISO for 2 months. Before and after therapy, the Hamilton Depression Rating Scale (HDRS) was applied to assess each participant's level of depression. Nuclear factor kappa B (NF-ĸB), biotinidase, high mobility group box protein (HMGB1), nucleotide-binding domain, leucine-rich-containing family, and pyrin domain-containing-3 (NLRP-3) were measured in serum samples.

resultsThere was no significant difference in all measured markers of healthy group before and after 2 months. Regarding group 2, there was a statistically significant decrease in all measured markers after 2 months of treatment and significant correlations between GAGS, NF-ĸB, HMGB1, NLRP3, biotinidase, and depression score.

conclusionIncreased GAGS, HMGB1, NLRP3, and biotinidase were associated with depression severity in AV patients and ISO treatment significantly reduced these parameters and reduced depressive symptoms.

Indexed as

Acne VulgarisBiomarkersBiotinidaseDepressionDermatologic AgentsIsotretinoinAdolescentAdultCase-Control StudiesFemaleHMGB1 ProteinHumansMaleNF-kappa BNLR Family, Pyrin Domain-Containing 3 ProteinSeverity of Illness IndexBiomarkersBiotinidaseDermatologic AgentsHMGB1 ProteinHMGB1 protein, humanIsotretinoinNF-kappa BNLR Family, Pyrin Domain-Containing 3 ProteinNLRP3 protein, humanacne vulgarisbiotinidasedepressionHMGB1NLRP3

Identifiers

PMID38923374
PMCPMC13648887

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.