Evidence map›Paper›PMID 38922923›Full record

ReviewBioEssays : news and reviews in molecular, cellular and developmental biology2024

Cited2 is a key regulator of placental development and plasticity.

Marija Kuna, Michael J Soares

Abstract readReview
In one paragraph

Review in BioEssays : news and reviews in molecular, cellular and developmental biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Marija KunaInstitute for Reproductive and Developmental Sciences, University of Kansas Medical Center, Kansas City, Kansas, USA.
Michael J SoaresInstitute for Reproductive and Developmental Sciences, University of Kansas Medical Center, Kansas City, Kansas, USA.ORCID 0000-0001-7158-1592

Funding

TROPHOBLAST DIFFERENTIATIONR01HD020676 · NICHD · UNIVERSITY OF KANSAS MEDICAL CENTER · PI MICHAEL J SOARES · 1986 to 2026
$10.1M
Anti-Coagulation Factors and PlacentationR01HD099638 · NICHD · UNIVERSITY OF KANSAS MEDICAL CENTER · PI SOARES, MICHAEL J · 2019 to 2023
$2.5M
Trophoblast-Guided Uterine Transformation in the Establishment of PregnancyR01HD105734 · NICHD · UNIVERSITY OF KANSAS MEDICAL CENTER · PI MICHAEL J SOARES · 2022 to 2026
$2.2M
Pathways Affecting Trophoblast DevelopmentR01HD112559 · NICHD · UNIVERSITY OF KANSAS MEDICAL CENTER · PI MICHAEL J SOARES, Geetu Tuteja · 2024 to 2026
$1.9M
NICHD NIH HHS R01 HD020676NICHD NIH HHS R01 HD099638NICHD NIH HHS R01 HD105734NICHD NIH HHS R01 HD112559NIH HHS HD020676NIH HHS HD099638NIH HHS HD105734NIH HHS HD112559Sosland Foundation
6 · The paper itself

Abstract

The biology of trophoblast cell lineage development and placentation is characterized by the involvement of several known transcription factors. Central to the action of a subset of these transcriptional regulators is CBP-p300 interacting transactivator with Glu/Asp-rich carboxy-terminal domain 2 (CITED2). CITED2 acts as a coregulator modulating transcription factor activities and affecting placental development and adaptations to physiological stressors. These actions of CITED2 on the trophoblast cell lineage and placentation are conserved across the mouse, rat, and human. Thus, aspects of CITED2 biology in hemochorial placentation can be effectively modeled in the mouse and rat. In this review, we present information on the conserved role of CITED2 in the biology of placentation and discuss the use of CITED2 as a tool to discover new insights into regulatory mechanisms controlling placental development.

Indexed as

PlacentationRepressor ProteinsTrans-ActivatorsTrophoblastsAnimalsFemaleGene Expression Regulation, DevelopmentalHumansMicePlacentaPregnancyRatsTranscription FactorsCITED2 protein, humanCited2 protein, mouseCITED2 protein, ratRepressor ProteinsTrans-ActivatorsTranscription FactorsCITED2HIF1modulatorplacentationTFAP2Ctrophoblast

Identifiers

PMID38922923
PMCPMC11331489

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.