Evidence map›Paper›PMID 38922850›Full record

ArticleMolecular biology of the cell2024

A novel protein Moat prevents ectopic epithelial folding by limiting Bazooka/Par3-dependent adherens junctions.

Lingkun Gu, Rolin Sauceda, Jasneet Brar, Ferdos Fessahaye, Minsang Joo, Joan Lee, Jacqueline Nguyen, Marissa Teng, Mo Weng

Abstract read
In one paragraph

Article in Molecular biology of the cell, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Lingkun GuSchool of Life Sciences, University of Nevada, Las Vegas, NV 89154.ORCID 0000-0002-6364-0094
Rolin SaucedaSchool of Life Sciences, University of Nevada, Las Vegas, NV 89154.
Jasneet BrarSchool of Life Sciences, University of Nevada, Las Vegas, NV 89154.
Ferdos FessahayeSchool of Life Sciences, University of Nevada, Las Vegas, NV 89154.
Minsang JooSchool of Life Sciences, University of Nevada, Las Vegas, NV 89154.
Joan LeeDepartment of Molecular Biology, Princeton University, Princeton, NJ 08544.
Jacqueline NguyenSchool of Life Sciences, University of Nevada, Las Vegas, NV 89154.
Marissa TengSchool of Life Sciences, University of Nevada, Las Vegas, NV 89154.
Mo WengSchool of Life Sciences, University of Nevada, Las Vegas, NV 89154.ORCID 0000-0001-9144-8772

Funding

Mechanosensitive remodeling of adherens junctions during snail-driven EMTR00HD088764 · NICHD · UNIVERSITY OF NEVADA LAS VEGAS · PI WENG, MO · 2018 to 2020
$742k
Mechanosensitive remodeling of adherens junctions during snail-driven EMTK99HD088764 · NICHD · PRINCETON UNIVERSITY · PI WENG, MO · 2016 to 2017
$179k
NICHD NIH HHS K99 HD088764NICHD NIH HHS R00 HD088764
6 · The paper itself

Abstract

Contractile myosin and cell adhesion work together to induce tissue shape changes, but how they are patterned to achieve diverse morphogenetic outcomes remains unclear. Epithelial folding occurs via apical constriction, mediated by apical contractile myosin engaged with adherens junctions, as in Drosophila ventral furrow formation. While it has been shown that a multicellular gradient of myosin contractility determines folding shape, the impact of multicellular patterning of adherens junction levels on tissue folding is unknown. We identified a novel Drosophila gene

Indexed as

Adherens JunctionsCell PolarityDrosophila melanogasterDrosophila ProteinsAnimalsCell AdhesionEpithelial CellsEpitheliumIntracellular Signaling Peptides and ProteinsMorphogenesisMyosinsbaz protein, DrosophilaDrosophila ProteinsIntracellular Signaling Peptides and ProteinsMyosins

Identifiers

PMID38922850
PMCPMC11321041

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.