ArticleThe Plant journal : for cell and molecular biology2024
The R2R3 MYB Ruby1 is activated by two cold responsive ethylene response factors, via the retrotransposon in its promoter, to positively regulate anthocyanin biosynthesis in citrus.
Article in The Plant journal : for cell and molecular biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- Cold-induced anthocyanin regulation in horticultural crops: mechanistic basis, trade-offs, and decision-driven temperature management in plant factories.Horticulture research · 2026Review
- Ethylene-responsive CmERF3-CmMYB4 cascade suppresses anthocyanin biosynthesis inHorticulture research · 2026Article
- Review
- Loss-of-Function Mutation in CER2-LIKE1 Reduced Accumulation of Cuticular Wax and Susceptibility to Thrips in Welsh Onion.Plant biotechnology journal · 2026Article
- Molecular insights into the regulation of flavonoid biosynthesis in fruits.Horticulture research · 2026Article
- VvERF045 Integrates Ethylene, Brassinosteroid and Abscisic Acid Pathways to Orchestrate Anthocyanin Biosynthesis in Grapevine.Plant biotechnology journal · 2026Article
- Genome-Wide Identification of R2R3-MYB Gene Family in Strawberry (International journal of molecular sciences · 2026Article
- Metabolic profiling of red-fleshed apple and functional characterization of MdERF072 in anthocyanin biosynthesis.BMC plant biology · 2025Article
- Transcriptome and Anthocyanin Profile Analysis Reveals That Exogenous Ethylene Regulates Anthocyanin Biosynthesis in Grape Berries.Foods (Basel, Switzerland) · 2025Article
- A Comprehensive Review of Phenolic Compounds in Horticultural Plants.International journal of molecular sciences · 2025Review
- Anthocyanin pathway in eggplant: genetic regulation and future directions for metabolic engineering.Molecular biology reports · 2025Review
- Flavonoids as key players in cold tolerance: molecular insights and applications in horticultural crops.Horticulture research · 2025Article
- Article
- Transcriptomic and targeted metabolomic analysis identifies genes involved in differential anthocyanin accumulation in potato tubers.Frontiers in plant science · 2025Article
- Unlocking the potential of flavonoid biosynthesis through integrated metabolic engineering.Frontiers in plant science · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
Anthocyanins are natural pigments and dietary antioxidants that play multiple biological roles in plants and are important in animal and human nutrition. Low temperature (LT) promotes anthocyanin biosynthesis in many species including blood orange. A retrotransposon in the promoter of Ruby1, which encodes an R2R3 MYB transcription factor, controls cold-induced anthocyanin accumulation in blood orange flesh. However, the specific mechanism remains unclear. In this study, we characterized two LT-induced ETHYLENE RESPONSE FACTORS (CsERF054 and CsERF061). Both CsERF054 and CsERF061 can activate the expression of CsRuby1 by directly binding to a DRE/CRT cis-element within the retrotransposon in the promoter of CsRuby1, thereby positively regulating anthocyanin biosynthesis. Further investigation indicated that CsERF061 also forms a protein complex with CsRuby1 to co-activate the expression of anthocyanin biosynthetic genes, providing a dual mechanism for the upregulation of the anthocyanin pathway. These results provide insights into how LT mediates anthocyanin biosynthesis and increase the understanding of the regulatory network of anthocyanin biosynthesis in blood orange.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.