ReviewJAMA surgery2024
Preventing Surgical Site Infections in the Era of Escalating Antibiotic Resistance and Antibiotic Stewardship.
Review in JAMA surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Intrawound vancomycin for prevention of surgical site infection: meta-analysis of randomized clinical trials.BJS open · 2026Pooled it
- Ertapenem as an Antibiotic Prophylaxis for Colectomies and Laparotomies: A Systematic Review.Surgical infections · 2026Pooled it
- Role of wound protectors in preventing surgical site infection in patients undergoing abdominal surgery: a meta-analysis of randomized controlled trials.BMC surgery · 2025Pooled it
- Preoperative Antibiotic Administration Before Distal Radius Fracture ORIF and Postoperative Outcomes: A Propensity-Matched Cohort Study.Journal of hand surgery global online · 2027Article
- Antimicrobial Prophylaxis in Pediatric Transplantation: From Describing Heterogeneity to Reducing It.Pediatric transplantation · 2026Article
- Antibiotic prophylaxis for open lower extremity fractures: a comparative propensity-scored matched analysis of cefazolin vs. piperacillin-tazobactam.Archives of orthopaedic and trauma surgery · 2026Article
- Wound management practices in surgery for adolescent idiopathic scoliosis.Journal of spine surgery (Hong Kong) · 2026Article
- Do Urologists Adhere to Antibiotic Prophylaxis Guidelines prior to Cystoscopy?Urologia internationalis · 2026Article
- Perioperative nursing process-oriented bundled interventions and digital monitoring for the prevention of surgical site infections.Frontiers in medicine · 2026Review
- Use of Ultraviolet C-Radiation Therapy in Trauma and Orthopaedics: A Current State of Evidence.Cureus · 2026Review
- Genes and physiological strategies in bacterial antibiotic resistance.Frontiers in microbiology · 2026Review
- Friend or foe: the gut microbiota as a modulator of disease trajectory in trauma, surgery, and critical illness.Gut microbes · 2025Review
- Gut-Brain Axis and Perioperative Gut Microbiome in Postoperative Cognitive Dysfunction: Implications for Neurosurgical Patients.Medical sciences (Basel, Switzerland) · 2025Review
- Preparing the Bowel for Surgery in the Era of Microbiome Sciences.The Surgical clinics of North America · 2025Review
- Formulation and characterization of a sortase a inhibitor-loaded PMMA bone cement.RSC advances · 2025Article
- Important issues on the prevention of surgical site infections and the management of prophylactic antibiotics.World journal of gastrointestinal surgery · 2025Article
- Advancing surgical prehabilitation through microbiota modulation.Przeglad gastroenterologiczny · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Importance: According to the Centers for Disease Control and Prevention and governing bodies within the American College of Surgeons, the administration of antibiotics as prophylaxis against infection prior to a planned elective procedure is, with rare exception, routinely recommended. The goal of "getting to zero" infections remains a high priority for policymakers, practitioners, and certainly for patients. Observations: Despite the many advances in surgical technique, skin decontamination, sterile procedure, and enhanced recovery programs, surgical site infections continue to adversely affect procedures as diverse as dental implant surgery, joint arthroplasty, and major abdominal surgery. Although surgical site infection rates are at historically low levels, progress has stalled in recent reporting periods and such infections remain disabling, costly, and occasionally lethal. Stakeholders in the field, including surgeons, infectious diseases specialists, and industry, advocate for strategies emphasizing greater levels of intraoperative sterility or broader-spectrum antibiotic coverage as the most appropriate path forward. Conclusions and Relevance: The current emphasis on ever-increasing levels of intraoperative sterility and extended-spectrum antibiotic use are not sustainable long-term solutions. Continuing to escalate these approaches may contribute to unintended consequences including antimicrobial resistance. Principles of antimicrobial stewardship and microbiome sciences can be applied to inform a more effective and sustainable approach to infection prevention in the field of surgery.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.