ArticleThe Plant cell2024
NRC Immune receptor networks show diversified hierarchical genetic architecture across plant lineages.
Article in The Plant cell, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- Diverse haplotypes at a complex Solanum americanum locus confer resistance to Phytophthora infestans and P. capsici.The Plant cell · 2026Article
- Contrasting evolutionary patterns of helper and sensor NRC NLRs in lettuce reflect functional divergence following subfunctionalization.PLoS genetics · 2026Article
- Diversification and deployment of PRR and NLR immune receptors in potato.The Plant journal : for cell and molecular biology · 2026Review
- A potato late blight pathogen effector interacts with ENTH-domain protein TOL9a and an activated helper NLR to suppress immunity.Science advances · 2026Article
- The emerging role of kinase fusion proteins in cereal immunity.Nature genetics · 2026Review
- Rhizobium rhizogenes A4-derived strains mediate hyper-efficient transient gene expression in Nicotiana benthamiana and other solanaceous plants.Plant biotechnology journal · 2026Article
- Exploring fern pathosystems and immune receptors to bridge gaps in plant immunity.BMC biology · 2025Article
- A CNL protein forms an NLR pair with NRCX to modulate plant immunity.Stress biology · 2025Article
- A root-specific NLR network mediates immune signaling of resistance genes against plant parasitic nematodes.The Plant cell · 2025Article
- Helper NLR immune protein NRC3 evolved to evade inhibition by a cyst nematode virulence effector.PLoS genetics · 2025Article
- A disease resistance protein triggers oligomerization of its NLR helper into a hexameric resistosome to mediate innate immunity.Science advances · 2024Article
- Activation of plant immunity through conversion of a helper NLR homodimer into a resistosome.PLoS biology · 2024Article
- Birth and expansion of NRC immune receptors across the largest group of flowering plants.The Plant cell · 2024Article
- The NRC0 gene cluster of sensor and helper NLR immune receptors is functionally conserved across asterid plants.The Plant cell · 2024Article
- Subfunctionalization of NRC3 altered the genetic structure of the Nicotiana NRC network.PLoS genetics · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Plants' complex immune systems include nucleotide-binding domain and leucine-rich repeat-containing (NLR) proteins, which help recognize invading pathogens. In solanaceous plants, the NRC (NLR required for cell death) family includes helper NLRs that form a complex genetic network with multiple sensor NLRs to provide resistance against pathogens. However, the evolution and function of NRC networks outside solanaceous plants are currently unclear. Here, we conducted phylogenomic and macroevolutionary analyses comparing NLRs identified from different asterid lineages and found that NRC networks expanded significantly in most lamiids but not in Ericales and campanulids. Using transient expression assays in Nicotiana benthamiana, we showed that NRC networks are simple in Ericales and campanulids, but have high complexity in lamiids. Phylogenetic analyses grouped the NRC helper NLRs into three NRC0 subclades that are conserved, and several family-specific NRC subclades of lamiids that show signatures of diversifying selection. Functional analyses revealed that members of the NRC0 subclades are partially interchangeable, whereas family-specific NRC members in lamiids lack interchangeability. Our findings highlight the distinctive evolutionary patterns of the NRC networks in asterids and provide potential insights into transferring disease resistance across plant lineages.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.