Evidence map›Paper›PMID 38922152›Full record

ArticleToxins2024

Unveiling Tst3, a Multi-Target Gating Modifier Scorpion α Toxin from

Diogo Vieira Tibery, João Antonio Alves Nunes, Daniel Oliveira da Mata, Luis Felipe Santos Menezes, Adolfo Carlos Barros de Souza, Matheus de Freitas Fernandes-Pedrosa, Werner Treptow, Elisabeth Ferroni Schwartz

Abstract readComparative Study
In one paragraph

Article in Toxins, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Diogo Vieira TiberyLaboratório de Neurofarmacologia, Departamento de Ciências Fisiológicas, Universidade de Brasília (UnB), Brasília 70910-900, Distrito Federal, Brazil.ORCID 0000-0002-0962-099X
João Antonio Alves NunesLaboratório de Biologia Teórica e Computacional (LBTC), Departamento de Biologia Celular, Universidade de Brasília (UnB), Brasília 70910-900, Distrito Federal, Brazil.ORCID 0000-0002-4331-0266
Daniel Oliveira da MataLaboratório de Neurofarmacologia, Departamento de Ciências Fisiológicas, Universidade de Brasília (UnB), Brasília 70910-900, Distrito Federal, Brazil.
Luis Felipe Santos MenezesLaboratório de Neurofarmacologia, Departamento de Ciências Fisiológicas, Universidade de Brasília (UnB), Brasília 70910-900, Distrito Federal, Brazil.ORCID 0000-0002-2264-5016
Adolfo Carlos Barros de SouzaLaboratório de Neurofarmacologia, Departamento de Ciências Fisiológicas, Universidade de Brasília (UnB), Brasília 70910-900, Distrito Federal, Brazil.
Matheus de Freitas Fernandes-PedrosaLaboratório de Tecnologia e Biotecnologia Farmacêutica, Departamento de Farmácia, Universidade Federal do Rio Grande do Norte (UFRN), Natal 59012-570, Rio Grande do Norte, Brazil.ORCID 0000-0003-4221-9580
Werner TreptowLaboratório de Biologia Teórica e Computacional (LBTC), Departamento de Biologia Celular, Universidade de Brasília (UnB), Brasília 70910-900, Distrito Federal, Brazil.ORCID 0000-0003-4564-3205
Elisabeth Ferroni SchwartzLaboratório de Neurofarmacologia, Departamento de Ciências Fisiológicas, Universidade de Brasília (UnB), Brasília 70910-900, Distrito Federal, Brazil.ORCID 0000-0001-8239-4055

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Studies on the interaction sites of peptide toxins and ion channels typically involve site-directed mutations in toxins. However, natural mutant toxins exist among them, offering insights into how the evolutionary process has conserved crucial sequences for activities and molecular target selection. In this study, we present a comparative investigation using electrophysiological approaches and computational analysis between two alpha toxins from evolutionarily close scorpion species of the genus

Indexed as

ScorpionsScorpion VenomsAmino Acid SequenceAnimalsAnimals, PoisonousBrazilHumansIon Channel GatingXenopus laevisScorpion VenomsscorpionTityusTs3Tst3voltage gated sodium channelsα-toxin

Identifiers

PMID38922152
PMCPMC11209618

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.