Evidence map›Paper›PMID 38922124›Full record

ArticleG3 (Bethesda, Md.)2024

Characterization and trans-generation dynamics of mitogene pool in the silver carp (Hypophthalmichthys molitrix).

Jinlin Li, Hengshu Wu, Yingna Zhou, Manhong Liu, Yongheng Zhou, Jianing Chu, Elizabeth Kamili, Wenhui Wang, Jincheng Yang, Lijun Lin and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in G3 (Bethesda, Md.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jinlin LiCollege of Wildlife and Protected Area, Northeast Forestry University, Harbin 150040, China.
Hengshu WuCollege of Wildlife and Protected Area, Northeast Forestry University, Harbin 150040, China.
Yingna ZhouCollege of Wildlife and Protected Area, Northeast Forestry University, Harbin 150040, China.
Manhong LiuCollege of Wildlife and Protected Area, Northeast Forestry University, Harbin 150040, China.
Yongheng ZhouCollege of Wildlife and Protected Area, Northeast Forestry University, Harbin 150040, China.
Jianing ChuCollege of Wildlife and Protected Area, Northeast Forestry University, Harbin 150040, China.
Elizabeth KamiliCollege of Wildlife and Protected Area, Northeast Forestry University, Harbin 150040, China.
Wenhui WangCollege of Wildlife and Protected Area, Northeast Forestry University, Harbin 150040, China.
Jincheng YangCollege of Wildlife and Protected Area, Northeast Forestry University, Harbin 150040, China.
Lijun LinCollege of Wildlife and Protected Area, Northeast Forestry University, Harbin 150040, China.
Qi ZhangCollege of Wildlife and Protected Area, Northeast Forestry University, Harbin 150040, China.
Shuhui YangCollege of Wildlife and Protected Area, Northeast Forestry University, Harbin 150040, China.
Yanchun XuCollege of Wildlife and Protected Area, Northeast Forestry University, Harbin 150040, China.

Funding

Fundamental Research Funds for the Central Universities 2572017PZ02National Natural Science Foundation of China 32170517
6 · The paper itself

Abstract

Multicopied mitogenome are prone to mutation during replication often resulting in heteroplasmy. The derived variants in a cell, organ, or an individual animal constitute a mitogene pool. The individual mitogene pool is initiated by a small fraction of the egg mitogene pool. However, the characteristics and relationship between them has not yet been investigated. This study quantitatively analyzed the heteroplasmy landscape, genetic loads, and selection strength of the mitogene pool of egg and hatchling in the silver carp (Hypophthalmichthys molitrix) using high-throughput resequencing. The results showed heteroplasmic sites distribute across the whole mitogenome in both eggs and hatchlings. The dominant substitution was Transversion in eggs and Transition in hatching accounting for 95.23%±2.07% and 85.38%±6.94% of total HP sites, respectively. The total genetic loads were 0.293±0.044 in eggs and 0.228±0.022 in hatchlings (P=0.048). The dN/dS ratio was 58.03±38.98 for eggs and 9.44±3.93 for hatchlings (P=0.037). These results suggest that the mitogenomes were under strong positive selection in eggs with tolerance to variants with deleterious effects, while the selection was positive but much weaker in hatchlings showing marked quality control. Based on these findings, we proposed a trans-generation dynamics model to explain differential development mode of the two mitogene pool between oocyte maturation and ontogenesis of offspring. This study sheds light on significance of mitogene pool for persistence of populations and subsequent integration in ecological studies and conservation practices.

Indexed as

CarpsGenome, MitochondrialAnimalsHeteroplasmyHigh-Throughput Nucleotide SequencingSelection, GeneticheteroplasmyHypophthalmichthys molitrixmitogene poolsilver carptrans-generation dynamics

Identifiers

PMID38922124
PMCPMC11491513

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.