Evidence map›Paper›PMID 38922089›Full record

ArticleToxics2024

Leukocyte Telomere Length Mediates the Associations between Blood Lead and Cadmium with Hypertension among Adults in the United States: A Cross-Sectional Study.

Changping Ouyang, Yinan Yang, Jinhua Pan, Heming Liu, Xuemei Wang, Shengze Zhou, Xiaoru Shi, Yanxia Zhang, Dan Wang, Xiaobin Hu

Abstract read
In one paragraph

Article in Toxics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Changping OuyangInstitute of Epidemiology and Health Statistics, School of Public Health, Lanzhou University, No. 199 Donggang West Road, Chengguan District, Lanzhou 730000, China.
Yinan YangThe Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai 519000, China.
Jinhua PanInstitute of Epidemiology and Health Statistics, School of Public Health, Lanzhou University, No. 199 Donggang West Road, Chengguan District, Lanzhou 730000, China.
Heming LiuInstitute of Epidemiology and Health Statistics, School of Public Health, Lanzhou University, No. 199 Donggang West Road, Chengguan District, Lanzhou 730000, China.
Xuemei WangInstitute of Epidemiology and Health Statistics, School of Public Health, Lanzhou University, No. 199 Donggang West Road, Chengguan District, Lanzhou 730000, China.
Shengze ZhouInstitute of Epidemiology and Health Statistics, School of Public Health, Lanzhou University, No. 199 Donggang West Road, Chengguan District, Lanzhou 730000, China.
Xiaoru ShiInstitute of Epidemiology and Health Statistics, School of Public Health, Lanzhou University, No. 199 Donggang West Road, Chengguan District, Lanzhou 730000, China.
Yanxia ZhangInstitute of Epidemiology and Health Statistics, School of Public Health, Lanzhou University, No. 199 Donggang West Road, Chengguan District, Lanzhou 730000, China.
Dan WangInstitute of Epidemiology and Health Statistics, School of Public Health, Lanzhou University, No. 199 Donggang West Road, Chengguan District, Lanzhou 730000, China.
Xiaobin HuInstitute of Epidemiology and Health Statistics, School of Public Health, Lanzhou University, No. 199 Donggang West Road, Chengguan District, Lanzhou 730000, China.

Funding

Gansu Provincial Natural Science Foundation No. 23JRRA0969
6 · The paper itself

Abstract

There is evidence to support the links between lead and cadmium exposure with hypertension and also with leukocyte telomere length (LTL). The objective of this study is to investigate the role that LTL may play in the relationship between lead and cadmium exposure and hypertension. This study consisted of 3718 participants from the National Health and Nutrition Examination Survey (NHANES) 1999-2002. Logistic regression was used to analyze the relationship between blood metals with hypertension, and the mediating model was used to evaluate the mediating effect of LTL. In the fully adjusted model, both blood lead and cadmium ln-transformed concentrations were significantly positively associated with hypertension risk, as were all quartiles of blood lead. Additionally, we observed positive linear dose-response relationships with hypertension by restricted cubic spline analysis (both

Indexed as

blood cadmiumblood leadhypertensionleukocyte telomere length (LTL)mediationNHANES

Identifiers

PMID38922089
PMCPMC11209134

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.