Evidence map›Paper›PMID 38921956›Full record

ArticleeLife2024

FAK loss reduces BRAF

Chenxi Gao, Huaibin Ge, Shih-Fan Kuan, Chunhui Cai, Xinghua Lu, Farzad Esni, Robert E Schoen, Jing H Wang, Edward Chu, Jing Hu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Chenxi GaoDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, United States.
Huaibin GeUPMC Hillman Cancer Center, Division of Hematology and Oncology, Department of Medicine, University of Pittsburgh, Pittsburgh, United States.
Shih-Fan KuanDepartment of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, United States.
Chunhui CaiDepartment of Biomedical Informatics, University of Pittsburgh, Pittsburgh, United States.
Xinghua LuDepartment of Biomedical Informatics, University of Pittsburgh, Pittsburgh, United States.ORCID https://orcid.org/0000-0002-8599-2269
Farzad EsniDepartment of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, United States.ORCID https://orcid.org/0000-0002-0342-6862
Robert E SchoenDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, United States.
Jing H WangUPMC Hillman Cancer Center, Division of Hematology and Oncology, Department of Medicine, University of Pittsburgh, Pittsburgh, United States.
Edward ChuUPMC Hillman Cancer Center, Division of Hematology and Oncology, Department of Medicine, University of Pittsburgh, Pittsburgh, United States.
Jing HuDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, United States.ORCID https://orcid.org/0000-0002-1849-4550

Funding

WILD TYPE P53-BASED ADJUVANT IMMUNOTHERAPY FOR SCCHNP50CA097190 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Greg M. Delgoffe · 2004 to 2026
$49.6M
Targeting PYK2 for the treatment of PDACR01CA236965 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HU, JING · 2020 to 2024
$1.8M
Chemical pancreatectomy for chronic pancreatitis and pancreatic cancerR01DK120698 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ESNI, FARZAD, GITTES, GEORGE K. · 2019 to 2022
$1.8M
Evaluation of the Effect of Autoimmunity on Acinar-Derived Insulin Producing CellsR21AI158824 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ESNI, FARZAD · 2021 to 2022
$433k
National Institute of Allergy and Infectious Diseases AI158824NCI NIH HHS CA236965NCI NIH HHS P50 CA097190NCI NIH HHS R01 CA236965NIAID NIH HHS R21 AI158824NIDDK NIH HHS DK120698NIDDK NIH HHS R01 DK120698
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Cecal NeoplasmsFocal Adhesion Kinase 1Proto-Oncogene Proteins B-rafAnimalsCarcinogenesisErbB ReceptorsExtracellular Signal-Regulated MAP KinasesHumansMaleMAP Kinase Signaling SystemMicePhosphorylationReceptors, G-Protein-CoupledBRAF protein, humanBraf protein, mouseErbB ReceptorsExtracellular Signal-Regulated MAP KinasesFocal Adhesion Kinase 1Proto-Oncogene Proteins B-rafPTK2 protein, humanPtk2 protein, mouseReceptors, G-Protein-CoupledBRAFV600Ecancer biologycarcinogenesisEGFRERKFAKmouse

Identifiers

PMID38921956
PMCPMC11208045

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.