Evidence map›Paper›PMID 38921780›Full record

ArticlePathogens (Basel, Switzerland)2024

Peptide-Alkoxyamine Drugs: An Innovative Approach to Fight Schistosomiasis: "Digging Their Graves with Their Forks".

Ange W Embo-Ibouanga, Michel Nguyen, Jean-Patrick Joly, Mathilde Coustets, Jean-Michel Augereau, Lucie Paloque, Nicolas Vanthuyne, Raphaël Bikanga, Anne Robert, Françoise Benoit-Vical and 4 more

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pathogens (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Ange W Embo-IbouangaAix-Marseille University, CNRS, UMR 7273, Case 551, Avenue Escadrille Normandie-Niemen, CEDEX 20, 13397 Marseille, France.
Michel NguyenLaboratoire de Chimie de Coordination (LCC-CNRS) and, New Antimalarial Molecules and Pharmacological Approaches (MAAP), Inserm ERL 1289, Université de Toulouse, CNRS, 31077 Toulouse, France.ORCID 0000-0002-6496-0495
Jean-Patrick JolyAix-Marseille University, CNRS, UMR 7273, Case 551, Avenue Escadrille Normandie-Niemen, CEDEX 20, 13397 Marseille, France.ORCID 0000-0002-4844-7499
Mathilde CoustetsLaboratoire de Chimie de Coordination (LCC-CNRS) and, New Antimalarial Molecules and Pharmacological Approaches (MAAP), Inserm ERL 1289, Université de Toulouse, CNRS, 31077 Toulouse, France.
Jean-Michel AugereauLaboratoire de Chimie de Coordination (LCC-CNRS) and, New Antimalarial Molecules and Pharmacological Approaches (MAAP), Inserm ERL 1289, Université de Toulouse, CNRS, 31077 Toulouse, France.ORCID 0000-0002-2847-1969
Lucie PaloqueLaboratoire de Chimie de Coordination (LCC-CNRS) and, New Antimalarial Molecules and Pharmacological Approaches (MAAP), Inserm ERL 1289, Université de Toulouse, CNRS, 31077 Toulouse, France.ORCID 0000-0003-0359-3959
Nicolas VanthuyneAix-Marseille University, CNRS, Centrale Marseille ISM2, Case 531, Avenue Escadrille Normandie-Niemen, CEDEX 20, 13397 Marseille, France.ORCID 0000-0003-2598-7940
Raphaël BikangaUniversité des Sciences et Techniques de Masuku, LASNSOM, Franceville BP 901, Gabon.
Anne RobertLaboratoire de Chimie de Coordination (LCC-CNRS) and, New Antimalarial Molecules and Pharmacological Approaches (MAAP), Inserm ERL 1289, Université de Toulouse, CNRS, 31077 Toulouse, France.ORCID 0000-0002-9092-6776
Françoise Benoit-VicalLaboratoire de Chimie de Coordination (LCC-CNRS) and, New Antimalarial Molecules and Pharmacological Approaches (MAAP), Inserm ERL 1289, Université de Toulouse, CNRS, 31077 Toulouse, France.ORCID 0000-0002-9468-4823
Gérard AudranAix-Marseille University, CNRS, UMR 7273, Case 551, Avenue Escadrille Normandie-Niemen, CEDEX 20, 13397 Marseille, France.
Philippe MelletMagnetic Resonance of Biological Systems, UMR 5536 CNRS-University of Bordeaux, 146 rue Leo Saignat, CEDEX, 33076 Bordeaux, France.ORCID 0000-0001-5499-9735
Jérôme BoissierIHPE, CNRS, Ifremer, University Perpignan Via Domitia, 66860 Perpignan, France.ORCID 0000-0002-0793-3108
Sylvain R A MarqueAix-Marseille University, CNRS, UMR 7273, Case 551, Avenue Escadrille Normandie-Niemen, CEDEX 20, 13397 Marseille, France.

Funding

Agence Nationale de la Recherche ANR-17-CE18-0017Fondation pour la Recherche Médicale EQU202103012596
6 · The paper itself

Abstract

The expansion of drug resistant parasites sheds a serious concern on several neglected parasitic diseases. Our recent results on cancer led us to envision the use of peptide-alkoxyamines as a highly selective and efficient new drug against schistosome adult worms, the etiological agents of schistosomiasis. Indeed, the peptide tag of the hybrid compounds can be hydrolyzed by worm's digestive enzymes to afford a highly labile alkoxyamine which homolyzes spontaneously and instantaneously into radicals-which are then used as a drug against Schistosome adult parasites. This approach is nicely summarized as

Indexed as

PeptidesSchistosomiasisAnimalsAnthelminticsHumansSchistosomaAnthelminticsPeptidesalkoxyaminesnew conceptprodrugschistosoma

Identifiers

PMID38921780
PMCPMC11206678

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.