Evidence map›Paper›PMID 38921542›Full record

ReviewJournal of functional biomaterials2024

Unveiling Nanoparticles: Recent Approaches in Studying the Internalization Pattern of Iron Oxide Nanoparticles in Mono- and Multicellular Biological Structures.

Teodora Eliana Petcov, Mihai Straticiuc, Decebal Iancu, Dragoș Alexandru Mirea, Roxana Trușcă, Paul Emil Mereuță, Diana Iulia Savu, George Dan Mogoșanu, Laurențiu Mogoantă, Roxana Cristina Popescu and 2 more

Abstract readReview
In one paragraph

Review in Journal of functional biomaterials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Teodora Eliana PetcovDepartment of Bioengineering and Biotechnology, Faculty of Medical Engineering, National University for Science and Technology Politehnica of Bucharest, 1-7 Gheorghe Polizu Street, 011061 Bucharest, Romania.
Mihai StraticiucDepartment of Applied Nuclear Physics, National Institute for R&D in Physics and Nuclear Engineering "Horia Hulubei", 30 Reactorului Street, 077125 Magurele, Romania.ORCID 0000-0001-9954-614X
Decebal IancuDepartment of Applied Nuclear Physics, National Institute for R&D in Physics and Nuclear Engineering "Horia Hulubei", 30 Reactorului Street, 077125 Magurele, Romania.ORCID 0000-0002-1007-1799
Dragoș Alexandru MireaDepartment of Applied Nuclear Physics, National Institute for R&D in Physics and Nuclear Engineering "Horia Hulubei", 30 Reactorului Street, 077125 Magurele, Romania.
Roxana TrușcăNational Research Center for Micro and Nanomaterials, National University for Science and Technology Politehnica of Bucharest, 313 Splaiul Independentei, 060042 Bucharest, Romania.
Paul Emil MereuțăDepartment of Applied Nuclear Physics, National Institute for R&D in Physics and Nuclear Engineering "Horia Hulubei", 30 Reactorului Street, 077125 Magurele, Romania.ORCID 0000-0002-9911-4766
Diana Iulia SavuDepartment of Life and Environmental Physics, National Institute for R&D in Physics and Nuclear Engineering "Horia Hulubei", 30 Reactorului Street, 077125 Magurele, Romania.ORCID 0000-0002-0145-5176
George Dan MogoșanuDepartment of Pharmacognosy & Phytotherapy, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, 2 Petru Rareș Street, 200349 Craiova, Romania.ORCID 0000-0001-6338-9277
Laurențiu MogoantăResearch Center for Microscopic Morphology and Immunology, University of Medicine and Pharmacy of Craiova, 2 Petru Rareș Street, 200349 Craiova, Romania.
Roxana Cristina PopescuDepartment of Bioengineering and Biotechnology, Faculty of Medical Engineering, National University for Science and Technology Politehnica of Bucharest, 1-7 Gheorghe Polizu Street, 011061 Bucharest, Romania.
Verena KopatzDepartment of Radiation Oncology, Medical University of Vienna, 18-20 Waehringer Guertel Street, 1090 Vienna, Austria.ORCID 0000-0002-7512-1398
Sorin Ion JingaDepartment of Bioengineering and Biotechnology, Faculty of Medical Engineering, National University for Science and Technology Politehnica of Bucharest, 1-7 Gheorghe Polizu Street, 011061 Bucharest, Romania.

Funding

National Program for Research of the National Association of Technical Universities - GNAC ARUT 2023 75/11.10.2023Romanian Ministry of Research Innovation and Digitalization PN-23-21-02-02
6 · The paper itself

Abstract

Nanoparticle (NP)-based solutions for oncotherapy promise an improved efficiency of the anticancer response, as well as higher comfort for the patient. The current advancements in cancer treatment based on nanotechnology exploit the ability of these systems to pass biological barriers to target the tumor cell, as well as tumor cell organelles. In particular, iron oxide NPs are being clinically employed in oncological management due to this ability. When designing an efficient anti-cancer therapy based on NPs, it is important to know and to modulate the phenomena which take place during the interaction of the NPs with the tumor cells, as well as the normal tissues. In this regard, our review is focused on highlighting different approaches to studying the internalization patterns of iron oxide NPs in simple and complex 2D and 3D in vitro cell models, as well as in living tissues, in order to investigate the functionality of an NP-based treatment.

Indexed as

biodistributionenergy dispersive X-ray spectroscopy (EDX)internalization methodsiron oxide nanoparticles (IONPs)monocellular modelsmulticellular modelsnanoparticles internalizationoptical microscopyparticle induced X-ray emission (PIXE)scanning electron microscopy (SEM)

Identifiers

PMID38921542
PMCPMC11204647

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.