Evidence map›Paper›PMID 38920958›Full record

ArticleGels (Basel, Switzerland)2024

Eco-Friendly Production of Polyvinyl Alcohol/Carboxymethyl Cellulose Wound Healing Dressing Containing Sericin.

Massimo Mariello, Enrico Binetti, Maria Teresa Todaro, Antonio Qualtieri, Virgilio Brunetti, Pietro Siciliano, Massimo De Vittorio, Laura Blasi

Abstract read
In one paragraph

Article in Gels (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Temperature- and pH-Responsive Poly(NIPAM-Gels (Basel, Switzerland) · 2025
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Massimo MarielloCenter for Biomolecular Nanotechnologies, Italian Institute of Technology, 73100 Lecce, Italy.ORCID 0000-0002-2750-0422
Enrico BinettiCenter for Biomolecular Nanotechnologies, Italian Institute of Technology, 73100 Lecce, Italy.ORCID 0000-0002-8088-2028
Maria Teresa TodaroCenter for Biomolecular Nanotechnologies, Italian Institute of Technology, 73100 Lecce, Italy.ORCID 0000-0001-6471-0843
Antonio QualtieriCenter for Biomolecular Nanotechnologies, Italian Institute of Technology, 73100 Lecce, Italy.ORCID 0000-0002-2207-8111
Virgilio BrunettiCenter for Biomolecular Nanotechnologies, Italian Institute of Technology, 73100 Lecce, Italy.
Pietro SicilianoInstitute for Microelectronics and Microsystems IMM-CNR, UOS di Lecce Via Monteroni c/o Campus Universitario Ecotekne-Palazzina A3, 73100 Lecce, Italy.ORCID 0000-0002-1312-4593
Massimo De VittorioCenter for Biomolecular Nanotechnologies, Italian Institute of Technology, 73100 Lecce, Italy.ORCID 0000-0003-1601-6392
Laura BlasiCenter for Biomolecular Nanotechnologies, Italian Institute of Technology, 73100 Lecce, Italy.

Funding

Regione Puglia "Lab on a Swab" (cod. OTHZY54).
6 · The paper itself

Abstract

Wound dressing production represents an important segment in the biomedical healthcare field, but finding a simple and eco-friendly method that combines a natural compound and a biocompatible dressing production for biomedical application is still a challenge. Therefore, the aim of this study is to develop wound healing dressings that are environmentally friendly, low cost, and easily produced, using natural agents and a physical crosslinking technique. Hydrogel wound healing dressings were prepared from polyvinyl alcohol/carboxymethyl cellulose and sericin using the freeze-thawing method as a crosslinking method. The morphological characterization was carried out by scanning electron microscopy (SEM), whereas the mechanical analysis was carried out by dynamic mechanical analysis (DMA) to test the tensile strength and compression properties. Then, the healing property of the wound dressing material was tested by in vitro and ex vivo tests. The results show a three-dimensional microporous structure with no cytotoxicity, excellent stretchability with compressive properties similar to those of human skin, and excellent healing properties. The proposed hydrogel dressing was tested in vitro with HaCaT keratinocytes and ex vivo with epidermal tissues, demonstrating an effective advantage on wound healing acceleration. Accordingly, this study was successful in developing wound healing dressings using natural agents and a simple and green crosslinking method.

Indexed as

dressingeco-friendlyhydrogelwound healing

Identifiers

PMID38920958
PMCPMC11202596

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.