Evidence map›Paper›PMID 38920954›Full record

ArticleGels (Basel, Switzerland)2024

The Diels-Alder Cross-Linked Gelatin/Dextran Nanocomposite Hydrogels with Silver Nanoparticles for Wound Healing Applications: Synthesis, Characterization, and In Vitro Evaluation.

Iman Gholamali, Sung-Han Jo, Won Han, Juhee Lim, Ali Rizwan, Sang-Hyug Park, Kwon Taek Lim

Abstract read
In one paragraph

Article in Gels (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Iman GholamaliIndustry 4.0 Convergence Bionics Engineering, Pukyong National University, Busan 48513, Republic of Korea.
Sung-Han JoIndustry 4.0 Convergence Bionics Engineering, Pukyong National University, Busan 48513, Republic of Korea.
Won HanIndustry 4.0 Convergence Bionics Engineering, Pukyong National University, Busan 48513, Republic of Korea.
Juhee LimIndustry 4.0 Convergence Bionics Engineering, Pukyong National University, Busan 48513, Republic of Korea.
Ali RizwanDepartment of Smart Green Technology Engineering, Pukyong National University, Busan 48513, Republic of Korea.
Sang-Hyug ParkIndustry 4.0 Convergence Bionics Engineering, Pukyong National University, Busan 48513, Republic of Korea.
Kwon Taek LimInstitute of Display Semiconductor Technology, Pukyong National University, Busan 48513, Republic of Korea.ORCID 0000-0002-7023-6057

Funding

National Research Foundation of Korea NRF-2022R1A2C1091873National Research Foundation of Korea NRF-2023R1A2C1002954
6 · The paper itself

Abstract

Wound healing involves a sophisticated biological process that relies on ideal conditions to advance through various stages of repair. Modern wound dressings are designed to imitate the natural surroundings around cells and offer properties such as moisture regulation, strength, and antimicrobial defense to boost healing. A recent research project unveiled a new type of gelatin (Gel)/dextran (Dex) hydrogels, linked through Diels-Alder (D-A) reactions, loaded with silver nanoparticles (Ag-NPs) for cutting-edge wound treatment. Gel and Dex were chemically modified to form the hydrogels via the D-A reaction. The hydrogels were enriched with Ag-NPs at varying levels. Thorough analyses of the hydrogels using methods like NMR, FT-IR, and SEM were carried out to assess their structure and nanoparticle integration. Rheological tests displayed that the hydrogels had favorable mechanical attributes, particularly when Ag-NPs were included. The hydrogels demonstrated controlled swelling, responsiveness to pH changes, and were non-toxic. Testing against E. coli showcased the strong antibacterial activity of the nanocomposite hydrogels in a concentration-dependent manner. This investigation showcased the promise of these bioactive nanocomposite hydrogels in promoting speedy wound healing by maintaining a moist environment, offering an antimicrobial shield, and ensuring mechanical support at the wound site.

Indexed as

Diels-Alder cross-linkedhydrogelssilver nanoparticleswound healing

Identifiers

PMID38920954
PMCPMC11202739

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.