Evidence map›Paper›PMID 38920851›Full record

ReviewDentistry journal2024

The Use of Statins as an Adjunctive Periodontal Disease Treatment: Systematic Review and Meta-Analysis.

Alice Rose Greethurst, Cosimo Galletti, Roberto Lo Giudice, José Nart, Cristina Vallés, Francisco Real-Voltas, Cosme Gay-Escoda, Enrico Marchetti

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Dentistry journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Alice Rose GreethurstSchool of Dentistry, Department of Integrated Dentistry, International University of Catalonia, Sant Cugat del Vallès, 08022 Barcelona, Spain.ORCID 0009-0002-7584-7524
Cosimo GallettiSchool of Dentistry, Department of Integrated Dentistry, International University of Catalonia, Sant Cugat del Vallès, 08022 Barcelona, Spain.ORCID 0000-0001-9938-4187
Roberto Lo GiudiceDepartment of Human Pathology of Adults and Developmental Age, Messina University, 98100 Messina, Italy.ORCID 0000-0002-3529-709X
José NartDepartment of Periodontology, International University of Catalonia, Sant Cugat del Vallès, 08022 Barcelona, Spain.
Cristina VallésDepartment of Periodontology, International University of Catalonia, Sant Cugat del Vallès, 08022 Barcelona, Spain.
Francisco Real-VoltasSchool of Dentistry, Department of Integrated Dentistry, International University of Catalonia, Sant Cugat del Vallès, 08022 Barcelona, Spain.ORCID 0000-0002-0805-5095
Cosme Gay-EscodaOral and Maxillofacial Surgery Department, School of Dentistry, University of Barcelona, 08022 Barcelona, Spain.
Enrico MarchettiDepartment of Life, Health and Environmental Sciences, University of l'Aquila, Piazzale Salvatore Tommasi 1, 67100 Coppito, Italy.ORCID 0000-0001-6461-7876

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundthe purpose of this systematic review was to assess the clinical and radiographic effect of subgingival-administered statins as an adjunct periodontal treatment in patients with periodontitis.

methodsElectronic literature searches in Medline/PubMed and the Cochrane Library were conducted to identify all relevant articles. Eligibility was based on inclusion criteria which included Randomized Controlled Trials (RCTs) published after 2010, where the periodontal variables were assessed before and after periodontal treatment in combination with a statin administration. The risk of bias was assessed with the ROBINS-2 tool. The outcome variables were probing depth, clinical attachment level, bleeding on probing, and bone fill in systematically healthy patients, patients with type 2 diabetes, and smokers.

resultsOut of 119 potentially eligible articles, 18 randomized controlled trials were included with a total of 1171 participants. The data retrieved from the meta-analysis showed the positive effect that statins have as an adjunctive periodontal disease treatment. When comparing the different types of statins, the PD reduction in the Simvastatin group was significantly higher than the Atorvastatin group at 6 months and at 9 months, while no differences between statins were found for the rest of the outcomes. Over 66% of the articles presented an overall risk of bias with some concerns, making this a limitation of this present RCT.

conclusionsThe adjunct administration of statins has proven to have a positive effect on the periodontium by improving both clinical and radiographic parameters by a considerable margin.

Indexed as

clinical parametersdiabetes mellitusperiodontitisradiographic parameterssmokingstatins

Identifiers

PMID38920851
PMCPMC11202911

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.