Evidence map›Paper›PMID 38920696›Full record

ArticleCells2024

Reduced Retinal Pigment Epithelial Autophagy Due to Loss of Rab12 Prenylation in a Human iPSC-RPE Model of Choroideremia.

Maide Ö Raeker, Nirosha D Perera, Athanasios J Karoukis, Lisheng Chen, Kecia L Feathers, Robin R Ali, Debra A Thompson, Abigail T Fahim

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Maide Ö RaekerDepartment of Ophthalmology, University of Michigan, Ann Arbor, MI 48105, USA.
Nirosha D PereraDepartment of Ophthalmology, University of Michigan, Ann Arbor, MI 48105, USA.
Athanasios J KaroukisDepartment of Ophthalmology, University of Michigan, Ann Arbor, MI 48105, USA.
Lisheng ChenDepartment of Orthopedic Surgery, University of Michigan, Ann Arbor, MI 48109, USA.
Kecia L FeathersDepartment of Ophthalmology, University of Michigan, Ann Arbor, MI 48105, USA.
Robin R AliDepartment of Ophthalmology, University of Michigan, Ann Arbor, MI 48105, USA.
Debra A ThompsonDepartment of Ophthalmology, University of Michigan, Ann Arbor, MI 48105, USA.
Abigail T FahimDepartment of Ophthalmology, University of Michigan, Ann Arbor, MI 48105, USA.ORCID 0000-0001-9737-054X

Funding

VIVARIUM MODULEP30EY007003 · NEI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI David Antonetti · 1987 to 2026
$17.6M
Investigating Membrane Trafficking Deficits in ChoroideremiaK08EY032991 · NEI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI FAHIM, ABIGAIL · 2021 to 2023
$713k
Choroideremia Research Foundation n/aNEI NIH HHS 1K08EY032991NEI NIH HHS K08 EY032991NEI NIH HHS P30 EY007003NEI NIH HHS P30EY007003Research to Prevent Blindness n/a
6 · The paper itself

Abstract

Choroideremia is an X-linked chorioretinal dystrophy caused by mutations in

Indexed as

AutophagyChoroideremiaInduced Pluripotent Stem Cellsrab GTP-Binding ProteinsRetinal Pigment EpitheliumAdaptor Proteins, Signal TransducingHumansMechanistic Target of Rapamycin Complex 1Models, BiologicalSignal TransductionAdaptor Proteins, Signal TransducingCHM protein, humanMechanistic Target of Rapamycin Complex 1Rab12 protein, humanrab GTP-Binding Proteinsautophagychoroideremiadisease modelinghuman pluripotent stem cellsinherited retinal diseaseretinal degenerationretinal pigment epithelium

Identifiers

PMID38920696
PMCPMC11201631

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.