Evidence map›Paper›PMID 38920688›Full record

ArticleCells2024

Down-Regulation of AKT Proteins Slows the Growth of Mutant-KRAS Pancreatic Tumors.

Chuankai Chen, Ya-Ping Jiang, Inchul You, Nathanael S Gray, Richard Z Lin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Loss of PIK3CA allowsbioRxiv : the preprint server for biology · 2026
    Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Chuankai ChenDepartment of Physiology & Biophysics, Stony Brook University, Stony Brook, NY 11794, USA.ORCID 0009-0009-7493-7537
Ya-Ping JiangDepartment of Physiology & Biophysics, Stony Brook University, Stony Brook, NY 11794, USA.
Inchul YouDepartment of Chemical and Systems Biology, ChEM-H, and Stanford Cancer Institute, Stanford School of Medicine, Stanford University, Stanford, CA 94305, USA.
Nathanael S GrayDepartment of Chemical and Systems Biology, ChEM-H, and Stanford Cancer Institute, Stanford School of Medicine, Stanford University, Stanford, CA 94305, USA.
Richard Z LinDepartment of Physiology & Biophysics, Stony Brook University, Stony Brook, NY 11794, USA.

Funding

PIK3CA signaling and pancreatic cancerR21CA274425 · NCI · STATE UNIVERSITY NEW YORK STONY BROOK · PI LIN, RICHARD Z · 2023 to 2024
$395k
The role of PI3K in pancreatic cancer genetics and progressionI01BX004083 · VA · NORTHPORT VA MEDICAL CENTER · PI LIN, RICHARD Z · 2018 to 2021
–
BLRD VA I01 BX004083NCI NIH HHS R21 CA274425NIH HHS 1R21CA274425-01A1
6 · The paper itself

Abstract

Serine/threonine kinase AKT isoforms play a well-established role in cell metabolism and growth. Most pancreatic adenocarcinomas (PDACs) harbor activation mutations of KRAS, which activates the PI3K/AKT signaling pathway. However, AKT inhibitors are not effective in the treatment of pancreatic cancer. To better understand the role of AKT signaling in mutant-KRAS pancreatic tumors, this study utilized proteolysis-targeting chimeras (PROTACs) and CRISPR-Cas9-genome editing to investigate AKT proteins. The PROTAC down-regulation of AKT proteins markedly slowed the growth of three pancreatic tumor cell lines harboring mutant KRAS. In contrast, the inhibition of AKT kinase activity alone had very little effect on the growth of these cell lines. The concurrent genetic deletion of all AKT isoforms (AKT1, AKT2, and AKT3) in the KPC (

Indexed as

Down-RegulationMutationPancreatic NeoplasmsProto-Oncogene Proteins c-aktProto-Oncogene Proteins p21(ras)AnimalsCell Line, TumorCell ProliferationGene Expression Regulation, NeoplasticHumansMiceSignal TransductionKRAS protein, humanProto-Oncogene Proteins c-aktProto-Oncogene Proteins p21(ras)AKTcholesterol metabolismIGF-1pancreatic cancer

Identifiers

PMID38920688
PMCPMC11202146

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.