Evidence map›Paper›PMID 38920617›Full record

ArticleBiosensors2024

Integrated High-Throughput Centrifugal Microfluidic Chip Device for Pathogen Detection On-Site.

Shuyu Lu, Yuanzhan Yang, Siqi Cui, Anyi Li, Cheng Qian, Xiaoqiong Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biosensors, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shuyu LuSchool of Medical Technology, Beijing Institute of Technology, 5 South Zhongguancun Street, Haidian District, Beijing 100081, China.
Yuanzhan YangSchool of Medical Technology, Beijing Institute of Technology, 5 South Zhongguancun Street, Haidian District, Beijing 100081, China.
Siqi CuiSchool of Medical Technology, Beijing Institute of Technology, 5 South Zhongguancun Street, Haidian District, Beijing 100081, China.
Anyi LiSchool of Medical Technology, Beijing Institute of Technology, 5 South Zhongguancun Street, Haidian District, Beijing 100081, China.
Cheng QianSchool of Medical Technology, Beijing Institute of Technology, 5 South Zhongguancun Street, Haidian District, Beijing 100081, China.
Xiaoqiong LiSchool of Medical Technology, Beijing Institute of Technology, 5 South Zhongguancun Street, Haidian District, Beijing 100081, China.

Funding

This research was funded by the Defense Industrial Technology Development Program (No. JCKY2021602B009)
6 · The paper itself

Abstract

An integrated and high-throughput device for pathogen detection is crucial in point-of-care testing (POCT), especially for early diagnosis of infectious diseases and preventing the spread of infection. We developed an on-site testing platform that utilizes a centrifugal microfluidic chip and automated device to achieve high-throughput detection. The low-power (<32 W), portable (220 mm × 220 mm × 170 mm, 4 kg) device can complete bacterial lysis, nucleic acid extraction and purification, loop-mediated isothermal amplification (LAMP) reaction, and real-time fluorescence detection. Magnetic beads for nucleic acid adsorption can be mixed by applying electromagnetic fields and centrifugal forces, and the efficiency of nucleic acid extraction is improved by 60% compared to the no-mixing group. The automated nucleic acid extraction process achieves equivalent nucleic acid extraction efficiency in only 40% of the time consumed using the kit protocol. By designing the valve system and disc layout, the maximum speed required for the centrifugal microfluidic chip is reduced to 1500 rpm, greatly reducing the equipment power consumption and size. In detecting

Indexed as

Lab-On-A-Chip DevicesNucleic Acid Amplification TechniquesBiosensing TechniquesCentrifugationEscherichia coliHumansLimit of DetectionMolecular Diagnostic Techniquescentrifugal microfluidic chipCoriolis forcedevicehydrophobic valvelampnucleic acid extractionparaffin valvesiphon valve

Identifiers

PMID38920617
PMCPMC11202104

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.