Evidence map›Paper›PMID 38920568›Full record

ArticleBiosensors2024

Fluorescence Multi-Detection Device Using a Lensless Matrix Addressable microLED Array.

Victor Moro, Joan Canals, Sergio Moreno, Steffen Higgins-Wood, Oscar Alonso, Andreas Waag, J Daniel Prades, Angel Dieguez

Abstract read
In one paragraph

Article in Biosensors, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Victor MoroElectronic and Biomedical Engineering Department, University of Barcelona, 08028 Barcelona, Spain.ORCID 0000-0002-6950-0981
Joan CanalsElectronic and Biomedical Engineering Department, University of Barcelona, 08028 Barcelona, Spain.ORCID 0000-0002-5431-8554
Sergio MorenoElectronic and Biomedical Engineering Department, University of Barcelona, 08028 Barcelona, Spain.ORCID 0000-0002-4471-1555
Steffen Higgins-WoodInstitute of Semiconductor Technology, Technical University of Braunschweig, 38106 Braunschweig, Germany.ORCID 0000-0002-7520-6615
Oscar AlonsoElectronic and Biomedical Engineering Department, University of Barcelona, 08028 Barcelona, Spain.
Andreas WaagInstitute of Semiconductor Technology, Technical University of Braunschweig, 38106 Braunschweig, Germany.
J Daniel PradesElectronic and Biomedical Engineering Department, University of Barcelona, 08028 Barcelona, Spain.
Angel DieguezElectronic and Biomedical Engineering Department, University of Barcelona, 08028 Barcelona, Spain.ORCID 0000-0001-6721-7245

Funding

European Union's Horizon 2020 737089MICIU/AEI /10.13039/501100011033 and by ESF invests in your future PRE2020-093659Ministry of Science and Innovation, the Spanish State Research Agency and the European Regional Development Fund PID2019-105714RB-I00
6 · The paper itself

Abstract

A Point-of-Care system for molecular diagnosis (PoC-MD) is described, combining GaN and CMOS chips. The device is a micro-system for fluorescence measurements, capable of analyzing both intensity and lifetime. It consists of a hybrid micro-structure based on a 32 × 32 matrix addressable GaN microLED array, with square LEDs of 50 µm edge length and 100 µm pitch, with an underneath wire bonded custom chip integrating their drivers and placed face-to-face to an array of 16 × 16 single-photon avalanche diodes (SPADs) CMOS. This approach replaces instrumentation based on lasers, bulky optical components, and discrete electronics with a full hybrid micro-system, enabling measurements on 32 × 32 spots. The reported system is suitable for long lifetime (>10 ns) fluorophores with a limit of detection ~1/4 µM. Proof-of-concept measurements of streptavidin conjugate Qdot™ 605 and Amino PEG Qdot™ 705 are demonstrated, along with the device ability to detect both fluorophores in the same measurement.

Indexed as

Biosensing TechniquesFluorescencePoint-of-Care SystemsSpectrometry, FluorescenceCMOSfluorescenceGaNlifetime fluorescencemicroLED arraymicroLED drivermultiplexPoint-of-CareSPAD

Identifiers

PMID38920568
PMCPMC11202237

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.