ArticleDiseases (Basel, Switzerland)2024
Cardiometabolic Risk Assessment in a Cohort of Children and Adolescents Diagnosed with Hyperinsulinemia.
Article in Diseases (Basel, Switzerland), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Article
- Insulin resistance in school-age children: comparison surrogate diagnostic markers.Pediatric research · 2026Article
- Obesity and Cardiometabolic Risk Factors Among Pediatric Patients at a Mississippi Academic Medical Center.American journal of health promotion : AJHP · 2026Observational
- Association between blood pressure and waist-to-height ratio in schoolchildren aged 6 to 8 years in the Valparaíso Region, Chile.Journal of preventive medicine and hygiene · 2025Article
- Pathophysiology of Prediabetes Hyperinsulinemia and Insulin Resistance in the Cardiovascular System.Biomedicines · 2025Review
- Genetic Variants in Metabolic Pathways and Their Role in Cardiometabolic Risk: An Observational Study of >4000 Individuals.Biomedicines · 2025Article
- Mapping the Fat: How Childhood Obesity and Body Composition Shape Obstructive Sleep Apnoea.Children (Basel, Switzerland) · 2025Review
- Prevalence and Metabolic Characterization of Polycystic Ovary Syndrome in a Cohort of Patients Diagnosed with Spina Bifida: Study Protocol.Children (Basel, Switzerland) · 2025Article
- Lipid Profile Alterations in Pediatric Patients with Vitamin D Deficiency.Children (Basel, Switzerland) · 2025Article
- In Vitro Chronic Hyperinsulinemia Induces Remodelling of Vascular Smooth Muscle Cells from Young Men and Women in a Sex Hormone Independent Manner.Pathophysiology : the official journal of the International Society for Pathophysiology · 2025Article
- The Impact of Acquired Hypothyroidism on the Growth and Metabolic Profiles of Pediatric Patients: A Retrospective Monocentric Study.Children (Basel, Switzerland) · 2025Article
- Association between weight-adjusted waist circumference index and risk of cognitive decline in Chinese hypertensive patients: a case-control study.Frontiers in public health · 2025Article
- Uncovering the inflammatory profile of obese children: examining the link between body mass index for age and insulin resistance in the Gaza Strip.Frontiers in pediatrics · 2025Article
- Nine anthropometric indices predict hepatic steatosis and assess liver health in adolescents: a population-based study.Frontiers in pediatrics · 2025Article
- Systemic Inflammation and Oxidative Stress in Childhood Obesity: Sex Differences in Adiposity Indices and Cardiovascular Risk.Biomedicines · 2024Article
- Predictive value of transabdominal pelvic ultrasonography for the diagnosis of central precocious puberty: A single-center observational retrospective study.Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology · 2024Article
- Current Practice of Children With Primary Hypertension: A Survey of Pediatricians in Thailand.Sage open pediatricsArticle
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Authors and funding
7 authors.
Funding
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Abstract
backgroundIndividuals with hyperinsulinemia may initially not meet any diagnostic criteria for metabolic syndrome, though displaying a higher risk of cardiovascular complications combined with obesity, diabetes, and hypertension.
aimThe main objective of our study was to assess the diagnostic accuracy of various cardiovascular risk indices in hyperinsulinemic children and adolescents; a secondary objective was to estimate the optimal cut-offs of these indices. PATIENTS AND
methodsThis retrospective single-center study was conducted on 139 patients aged 12.1 ± 2.9 years, managed for hyperinsulinism.
resultsWe found statistically significant differences in homeostasis model assessment of insulin resistance index (HOMA-IR), triglyceride glucose index (TyG), TyG-body mass index, visceral adiposity index, lipid accumulation product index, fatty liver index, and hepatic steatosis index. At the linear logistic regression assessment, we found that insulin growth factor-1 (IGF-1), HOMA-IR, and ALT/AST ratio were independently associated with confirmed hyperinsulinism. At the multivariate analysis, IGF-1 levels over 203 ng/mL and HOMA-IR higher than 6.2 were respectively associated with a 9- and 18-times higher odds ratio for hyperinsulinism. The other investigated parameters were not significantly related to hyperinsulinism, and could not predict either the presence of hyperinsulinemia or a subsequent cardiovascular risk in our patients.
conclusionCommonly used indices of cardiovascular risk in adults cannot be considered accurate in confirming hyperinsulinism in children, with the exception of HOMA-IR. Further studies are needed to verify the usefulness of specific cardiovascular risk indices in hyperinsulinemic children and adolescents.
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