Evidence map›Paper›PMID 38920076›Full record

ReviewCurrent medicinal chemistry2025

Toxic Effects of Methamphetamine on Reproductive Systems, Embryo Development, and Newborns: An Evidence-based Review.

Qianqian Chen, Lan Wang, Jinlong Zhang, Junzhe Cheng, Jiang Lin, Yilin Peng, Yuhang Liu, Changquan Zhang, Jie Yan, Shuliang Niu

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Sublethal Concentrations of 2C-I and 25I-NBOMe Designer Drugs ImpactInternational journal of molecular sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Qianqian ChenDepartment of Forensic Science, School of Basic Medical Science, Central South University, Changsha, Hunan, 410013, China.
Lan WangDepartment of Anatomy, School of Basic Medical Science, Central South University, Changsha, Hunan, 410013, China.
Jinlong ZhangDepartment of Forensic Science, School of Basic Medical Science, Central South University, Changsha, Hunan, 410013, China.
Junzhe ChengClinical Medicine Eight-Year Program, Xiangya School of Medicine, Central South University, Changsha, Hunan, China.
Jiang LinDepartment of Forensic Science, School of Basic Medical Science, Central South University, Changsha, Hunan, 410013, China.
Yilin PengDepartment of Forensic Science, School of Basic Medical Science, Central South University, Changsha, Hunan, 410013, China.
Yuhang LiuDepartment of Forensic Science, School of Basic Medical Science, Central South University, Changsha, Hunan, 410013, China.
Changquan ZhangDepartment of Forensic Science, School of Basic Medical Science, Central South University, Changsha, Hunan, 410013, China.
Jie YanDepartment of Forensic Science, School of Basic Medical Science, Central South University, Changsha, Hunan, 410013, China.
Shuliang NiuDepartment of Forensic Science, School of Basic Medical Science, Central South University, Changsha, Hunan, 410013, China.

Funding

National Natural Science Foundation of China 82060339, 82171494NHC Key Laboratory of Birth Defect for Research and Prevention (Hunan Provincial Maternal and Child Health Care Hospital) KF2021012
6 · The paper itself

Abstract

Methamphetamine (METH), an amphetamine-type stimulant, has been extensively abused globally in the past decades. METH use causes great harm to the major systems of the human body. Specifically, METH has a negative impact on the hypothalamic- pituitary-testicular axis, testicular structure, sperm function, ovarian folliculogenesis, oocyte quality, embryo development, and newborns. However, the mechanisms underlying these toxic effects have not yet been fully described. This study reviews the evidence concerning the impact of METH on male and female reproduction in the context of the testis, sperm, ovaries, oocytes, reproductive hormones, embryo development, and newborns, discussing the potential pathophysiological mechanisms in the reproductive toxicity induced by METH.

Indexed as

Central Nervous System StimulantsEmbryonic DevelopmentMethamphetamineReproductionAnimalsFemaleHumansInfant, NewbornMaleOvaryTestisCentral Nervous System StimulantsMethamphetamineembryo developmentMethamphetaminenewborns.oocytereproductionspermtestis

Identifiers

PMID38920076

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.