Evidence map›Paper›PMID 38919612›Full record

ArticleFrontiers in immunology2024

Acid ceramidase expression reduces IFNγ secretion by mouse CD4

Putri Mandasari, Claudia Hollmann, Rehan-Haider Zaidi, Samira Löw, Jann Schrama, Dominik Wigger, Fabian Schumacher, Burkhard Kleuser, Niklas Beyersdorf

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Putri MandasariInstitute for Virology and Immunobiology, University of Würzburg, Würzburg, Germany.
Claudia HollmannInstitute for Virology and Immunobiology, University of Würzburg, Würzburg, Germany.
Rehan-Haider ZaidiInstitute for Virology and Immunobiology, University of Würzburg, Würzburg, Germany.
Samira LöwInstitute for Virology and Immunobiology, University of Würzburg, Würzburg, Germany.
Jann SchramaInstitute for Virology and Immunobiology, University of Würzburg, Würzburg, Germany.
Dominik WiggerInstitute of Pharmacy, Freie Universität Berlin, Berlin, Germany.
Fabian SchumacherInstitute of Pharmacy, Freie Universität Berlin, Berlin, Germany.
Burkhard KleuserInstitute of Pharmacy, Freie Universität Berlin, Berlin, Germany.
Niklas BeyersdorfInstitute for Virology and Immunobiology, University of Würzburg, Würzburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acid ceramidase (Ac) is a lysosomal enzyme catalyzing the generation of sphingosine from ceramide, and Ac inhibitors are currently being investigated as potential cancer therapeutics. Yet, the role of the Ac in immune responses, particularly anti-viral immunity, is not fully understood. To investigate the impact of Ac expression on various leukocyte populations, we generated a tamoxifen-inducible global knockout mouse model for the Ac (iAc-KO). Following tamoxifen administration to healthy mice, we extracted primary and secondary lymphoid organs from iAc-KO and wild-type (wt) littermates and subsequently performed extensive flow cytometric marker analysis. In addition, we isolated CD4

Indexed as

Acid CeramidaseB-LymphocytesCD4-Positive T-LymphocytesInterferon-gammaMice, KnockoutAnimalsLymphocyte CountMiceMice, Inbred C57BLAcid CeramidaseIFNG protein, mouseInterferon-gammaacid ceramidaseB cell survivalCD4+ T cellcytokine secretioninducible knockout micein vitro culture assay

Identifiers

PMID38919612
PMCPMC11196608

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.