Evidence map›Paper›PMID 38919411›Full record

ArticleIJTLD open2024

Clinical spectrum of disease and outcomes in children with Omicron SARS-COV-2 infection in Cape Town, South Africa.

C Bekker, I Dewandel, A Redfern, C McKenzie, J Lishman, L M Verhagen, M Claassen, S Wilson, R Dunbar, C Bosch and 5 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in IJTLD open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06902194 (Mucosal Surveillance and Immunology of Respiratory Pathogens in South African Children Post the COVID-19 Pandemic), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06902194 recruitingnot on this map

Mucosal Surveillance and Immunology of Respiratory Pathogens in South African Children Post the COVID-19 Pandemic

TypeobservationalSponsorDesmond Tutu TB CentreRan2024 to 2025Enrolled250ConditionsRespiratory Tract Infections (RTI), Mucosal Immunity
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Launch ofIJTLD open · 2024
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  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

C BekkerDesmond Tutu TB Centre, and.
I DewandelDesmond Tutu TB Centre, and.
A RedfernDepartment of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
C McKenzieDesmond Tutu TB Centre, and.
J LishmanDepartment of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
L M VerhagenDepartment of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
M ClaassenDivision of Medical Virology, Stellenbosch University, Cape Town.
S WilsonDesmond Tutu TB Centre, and.
R DunbarDesmond Tutu TB Centre, and.
C BoschDesmond Tutu TB Centre, and.
G van ZylDivision of Medical Virology, Stellenbosch University, Cape Town.
W PreiserDivision of Medical Virology, Stellenbosch University, Cape Town.
P GoussardDepartment of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
H RabieDepartment of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
M M van der ZalmDesmond Tutu TB Centre, and.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionChildren with underlying comorbidities and infants are most severely affected by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection, including in low- and middle-income countries with a high prevalence of HIV and TB. We describe the clinical presentation of SARS-CoV-2 infection in children during the Omicron wave, in Cape Town, South Africa.

methodsWe analysed routine care data from a prospective cohort of children aged 0-13 years, with a positive SARS-CoV-2 real-time reverse-transcription polymerase chain reaction (rRT-PCR) or SARS-CoV-2 antigen test, admitted to Tygerberg Hospital between 1 November 2021 until 1 March 2022. Risk factors for severity of disease were assessed.

resultsNinety-five children tested positive for SARS-CoV-2, of whom 87 (91.6%) were symptomatic. Clinical data were available for 86 children. The median age was 11 months (IQR 3.0-60.0), 37 (43.0%) were females, 21 (24.7%) were HIV-exposed and 7 (8.1%) were living with HIV (CLHIV). In total, 44 (51.2%) children had at least one underlying comorbidity. TB co-infection was seen in 11 children, 6 children were newly diagnosed and 5 children were already on TB treatment at the time of admission.

conclusionThere was no evidence of more severe disease in children living with HIV or TB.

Indexed as

children living with HIVcomorbiditiesOmicronpaediatrictuberculosis

Identifiers

PMID38919411
PMCPMC11189602

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