Evidence map›Paper›PMID 38919334›Full record

ReviewMedComm2024

Nanoliposomes as nonviral vectors in cancer gene therapy.

Safiye Nur Yildiz, Maliheh Entezari, Mahshid Deldar Abad Paskeh, Sepideh Mirzaei, Alireza Kalbasi, Amirhossein Zabolian, Farid Hashemi, Kiavash Hushmandi, Mehrdad Hashemi, Mehdi Raei and 7 more

Abstract readReview
In one paragraph

Review in MedComm, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Safiye Nur YildizDepartment of Biomedical Engineering Erciyes University Kayseri Turkey.ORCID https://orcid.org/0009-0008-4896-5553
Maliheh EntezariDepartment of Genetics Faculty of Advanced Science and Technology Tehran Medical Sciences Islamic Azad University Tehran Iran.
Mahshid Deldar Abad PaskehDepartment of Genetics Faculty of Advanced Science and Technology Tehran Medical Sciences Islamic Azad University Tehran Iran.
Sepideh MirzaeiDepartment of Biology Faculty of Science Islamic Azad University Science and Research Branch Tehran Iran.
Alireza KalbasiDepartment of Pharmacy Brigham and Women's Hospital Harvard Medical School Boston Massachusetts USA.ORCID https://orcid.org/0000-0002-6657-4950
Amirhossein ZabolianDepartment of Orthopedics Shahid Beheshti University of Medical Sciences Tehran Iran.
Farid HashemiDepartment of Comparative Biosciences Faculty of Veterinary Medicine University of Tehran Tehran Iran.
Kiavash HushmandiDepartment of Clinical Sciences Institute Nephrology and Urology Research Center Baqiyatallah University of Medical Sciences Tehran Iran.
Mehrdad HashemiDepartment of Genetics Faculty of Advanced Science and Technology Tehran Medical Sciences Islamic Azad University Tehran Iran.
Mehdi RaeiDepartment of Epidemiology and Biostatistics School of Health Baqiyatallah University of Medical Sciences Tehran Iran.
Mohammad Ali Sheikh Beig GoharriziDepartment of Biotechnology College of Science, University of Tehran Tehran Iran.
Amir Reza ArefBelfer Center for Applied Cancer Science Dana-Farber Cancer Institute Harvard Medical School Boston Massachusetts USA.
Ali ZarrabiDepartment of Biomedical Engineering Faculty of Engineering and Natural Sciences Istinye University Istanbul Turkey.
Jun RenShanghai Institute of Cardiovascular Diseases Department of Cardiology Zhongshan Hospital Fudan University Shanghai China.
Gorka OriveNanoBioCel Research Group School of Pharmacy University of the Basque Country (UPV/EHU) Vitoria-Gasteiz Spain.
Navid RabieeCentre for Molecular Medicine and Innovative Therapeutics Murdoch University Perth Western Australia Australia.
Yavuz Nuri ErtasDepartment of Biomedical Engineering Erciyes University Kayseri Turkey.ORCID https://orcid.org/0000-0002-6791-7484

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nonviral vectors, such as liposomes, offer potential for targeted gene delivery in cancer therapy. Liposomes, composed of phospholipid vesicles, have demonstrated efficacy as nanocarriers for genetic tools, addressing the limitations of off-targeting and degradation commonly associated with traditional gene therapy approaches. Due to their biocompatibility, stability, and tunable physicochemical properties, they offer potential in overcoming the challenges associated with gene therapy, such as low transfection efficiency and poor stability in biological fluids. Despite these advancements, there remains a gap in understanding the optimal utilization of nanoliposomes for enhanced gene delivery in cancer treatment. This review delves into the present state of nanoliposomes as carriers for genetic tools in cancer therapy, sheds light on their potential to safeguard genetic payloads and facilitate cell internalization alongside the evolution of smart nanocarriers for targeted delivery. The challenges linked to their biocompatibility and the factors that restrict their effectiveness in gene delivery are also discussed along with exploring the potential of nanoliposomes in cancer gene therapy strategies by analyzing recent advancements and offering future directions.

Indexed as

CRISPR/Cas9liposomenonviral vectorshRNAsiRNA

Identifiers

PMID38919334
PMCPMC11199024

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.