Evidence map›Paper›PMID 38919297›Full record

ArticleIranian journal of public health2024

Inhibition of Mir-21-5p Affects the Expression of LNCRNA X-Inactive Specific Transcript and Induces Apoptosis in MCF-7 Breast Cancer Cells.

Samaneh Nejaddehghan, Seyed Jalal Zargar, Mana Oloomi, Kazem Baesi, Morteza Kouhsar

Abstract read
In one paragraph

Article in Iranian journal of public health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Samaneh NejaddehghanDepartment of Cell and Molecular Biology, School of Biology, College of Science, University of Tehran, Tehran, Iran.
Seyed Jalal ZargarDepartment of Cell and Molecular Biology, School of Biology, College of Science, University of Tehran, Tehran, Iran.
Mana OloomiDepartment of Molecular Biology, Pasteur Institute of Iran, Tehran, Iran.
Kazem BaesiDepartment of Hepatitis and AIDS, Pasteur Institute of Iran, Tehran, Iran.
Morteza KouhsarLaboratory of Systems Biology and Bioinformatics (IBB), Institute of Biochemistry and Biophysics (IBB), University of Tehran, Tehran, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: We aimed to investigate miR-21-5p inhibition effect on lncRNA-XIST expression and apoptosis status of MCF-7 cells. Methods: The MCF-7 cells were cultured and transfected by the anti-miR-21-5p oligonucleotide and expression of miR-21-5p, lncRNA-XIST, apoptosis-associated genes ( Results: Expression of miR-21-5p and lncRNA-XIST was significantly down- and up-regulated respectively ( Conclusion: Inhibition of miR-21-5p resulted in significant upregulation of lncRNA-XIST and apoptosis-associated genes

Indexed as

ApoptosisBreast cancerNon-coding RNAX-inactive specific transcript

Identifiers

PMID38919297
PMCPMC11194654

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.