ArticleClinical, cosmetic and investigational dermatology2024
First Cousin Marriages and the Risk of Childhood-Onset Vitiligo: Exploring the Genetic Background: A Cross-Sectional Study.
Article in Clinical, cosmetic and investigational dermatology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Breastfeeding, Family Stress, and Climate as Key Determinants of Atopic Dermatitis Severity in Children: A Cross-Sectional Study.Clinical, cosmetic and investigational dermatology · 2026Article
- The Psychological Burden of Vitiligo: Investigating the Depressive Symptoms in Patients with Vitiligo: A Case-Control Study.Medicina (Kaunas, Lithuania) · 2025Article
- The Role of Functional Polymorphisms of ApoptoticIranian journal of medical sciences · 2025Article
- Impact of Consanguinity and Familial Aggregation on Vitiligo Epidemiology in Saudi Arabia: A Case-Control Study.Cureus · 2024Article
- Vitiligo: Clinical and Laboratory Characteristics in 573 Saudi Patients.Clinical, cosmetic and investigational dermatology · 2024Article
Corrections and comments
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Authors and funding
3 authors.
Funding
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Abstract
Background: Vitiligo, a condition characterized by depigmented skin, has been observed to have a higher incidence in patients with a family history of the disease. This study investigates the relationship between parental consanguinity, family medical history, and the onset of childhood vitiligo, hypothesizing that genetic factors play a significant role. Methods: A cross-sectional study was conducted involving 382 people diagnosed with vitiligo in Saudi Arabia. The study assessed the prevalence of parental consanguinity and its correlation with the disease's onset, employing statistical analysis to evaluate the data collected through medical records and family history questionnaires. Results: The findings reveal a significant association between parental consanguinity, particularly among first cousins, and the incidence of childhood-onset vitiligo. Additionally, a notable correlation was found between family medical history and the onset of the condition, with familial vitiligo being more prevalent in patients with adult-onset vitiligo. Conclusion: This study underscores the critical role of genetic predispositions in the development of childhood-onset vitiligo, highlighting the influence of parental consanguinity. The results advocate for increased awareness and screening in populations with high rates of consanguinity to facilitate early detection and management of vitiligo. Future research should focus on exploring the genetic mechanisms underlying this association to develop targeted interventions.
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