ArticleClinical endoscopy2024
Systematic review of self-assembling peptides as topical agents for treatment and prevention of gastrointestinal bleeding.
Article in Clinical endoscopy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- Trial
- Use of the self-assembling peptide (PuraStat™) for the management and prevention of ERCP-related bleeding: a multicenter prospective cohort study.Surgical endoscopy · 2026Observational
- The role of enteroscopy in the diagnosis and interventional management of small intestine diseases.Therapeutic advances in gastroenterology · 2026Review
- Effect of a self-assembling peptide hydrogel on delayed bleeding following endoscopic sphincterotomy: Prospective pilot cohort study.Endoscopy international open · 2026Article
- Hemostatic Hold-Up: A Rare Case of Endoscopic Retention After Hemostatic Powder Application.ACG case reports journal · 2026Article
- Successful hemostasis of spurting gastric ulcer bleeding using self-assembling peptide gel.Endoscopy · 2025Article
- Advancement of haemostatic self-assembling peptides in the treatment of gastrointestinal bleeding: What role for PuraStatWorld journal of gastrointestinal endoscopy · 2025Article
- PuraStat as secondary therapy for hemostasis in Mallory-Weiss syndrome with oral antithrombotic medication.DEN open · 2025Article
- Post-polypectomy colorectal bleeding: current strategies and the way forward.Clinical endoscopy · 2025Review
- APPLICATION OF A TWO-COAT SELF-ASSEMBLING PEPTIDE HEMOSTATIC GEL TECHNIQUE IN MANAGING ENDOSCOPIC SPHINCTEROTOMY-RELATED BLEEDING: A CASE REPORT.Arquivos de gastroenterologia · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimsGastrointestinal bleeding is a significant and potentially lethal event. We aimed to review the efficiency and safety of self-assembling peptides for the treatment and prevention of gastrointestinal tract bleeding.
methodsWe conducted a systematic search for studies describing the endoscopic use of self-assembling peptides for treatment or prevention of bleeding in the gastrointestinal tract in a parallel, independent fashion. The primary outcomes were rates of successful initial hemostasis, delayed bleeding, and rebleeding. The secondary outcomes were adverse events and ease and volume of gel used.
resultsSeventeen studies were analyzed. Overall success rate of self-assembling peptides in gastrointestinal bleeding was 87.7% (38%-100%), regardless of etiology or associated treatments. Rebleeding rate ranged from 0% to 16.2%, with a mean of 4.7%, and overall delayed bleeding rate was 5% (range, 0%-15.9%). Only three adverse events were reported in a pooled number of 815 patients. The volume of gel used varied (0.43 to 3.7 mL) according to indication and type of bleeding.
conclusionsThe limited available data on the use of self-assembling peptides in gastrointestinal endoscopy suggest a high efficiency and good safety profile.
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