Evidence map›Paper›PMID 38918985›Full record

ArticleCurrent molecular medicine2025

CD4

Fakhfakh Raouia, Ben Jmaa Mariem, Elloumi Nesrine, Mseddi Meriam, Mohamed Mohany, Bahloul Emna, Khadija Sellami, Feki Sawsan, Marija Milošević, Turki Hamida and 2 more

Abstract read
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In one paragraph

Article in Current molecular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Fakhfakh Raouia"Autoimmunity, Cancer and Immunogenetics" Research Laboratory [LR18SP12], Immunology Department, Habib Bourguiba Hospital, University of Sfax, Sfax, Tunisia.
Ben Jmaa Mariem"Autoimmunity, Cancer and Immunogenetics" Research Laboratory [LR18SP12], Immunology Department, Habib Bourguiba Hospital, University of Sfax, Sfax, Tunisia.
Elloumi Nesrine"Autoimmunity, Cancer and Immunogenetics" Research Laboratory [LR18SP12], Immunology Department, Habib Bourguiba Hospital, University of Sfax, Sfax, Tunisia.
Mseddi MeriamLaboratory of Research "Molecular Basis of Human Diseases", LR19ES13, Faculty of Medicine, University of Sfax, Sfax, Tunisia.
Mohamed MohanyDepartment of Pharmacology and Toxicology, College of Pharmacy, King Saud University, P.O. Box 55760, Riyadh, 11451, Saudi Arabia.
Bahloul EmnaDermatology Department, Hedi Chaker Hospital, University of Sfax, Sfax, Tunisia.
Khadija SellamiDermatology Department, Hedi Chaker Hospital, University of Sfax, Sfax, Tunisia.
Feki SawsanImmunology Department, Habib Bourguiba Hospital, University of Sfax, Sfax, Tunisia.
Marija MiloševićDepartment of Biology and Ecology, Faculty of Science, University of Kragujevac, Kragujevac, 34000, Serbia.
Turki HamidaDermatology Department, Hedi Chaker Hospital, University of Sfax, Sfax, Tunisia.
Masmoudi Hatem"Autoimmunity, Cancer and Immunogenetics" Research Laboratory [LR18SP12], Immunology Department, Habib Bourguiba Hospital, University of Sfax, Sfax, Tunisia.
Abida Olfa"Autoimmunity, Cancer and Immunogenetics" Research Laboratory [LR18SP12], Immunology Department, Habib Bourguiba Hospital, University of Sfax, Sfax, Tunisia.

Funding

King Saud University, Riyadh, Saudi Arabia RSPD2024R758
6 · The paper itself

Abstract

backgroundT helper interplay and cytokines monitoring in auto-immune skin disorders such as Pemphigus Foliaceus (PF) may play a central role in predicting the clinical stratification of the pathology.

objectivesIn order to assess the CD4

methodsPeripheral blood of 22 PF patients was analyzed by flow cytometry to assess the functional associations of Th cell subpopulations and their characteristic cytokines by multiplex bead assay of 14-plex cytokines. Skin mRNA expression of their associated transcription factors was analyzed using the TaqMan detection system.

resultsOur findings revealed that the CD4

conclusionOur results highlight the central role played by Th17 lymphocytes and their related pro-inflammatory cytokines during the clinical course of the disease, reversing the Th1/Th2 dichotomy in PF.

Indexed as

CD4-Positive T-LymphocytesCytokinesPemphigusTh1 CellsTh2 CellsT-Lymphocyte SubsetsAdultAgedFemaleHumansMaleMiddle AgedSkinTh17 CellsCytokinesCD4+ T-cell.clinical stratificationcytokinesPemphiguspredictionTh classical phenotype

Identifiers

PMID38918985

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.