Evidence map›Paper›PMID 38918903›Full record

Observational studyEndocrinology and metabolism (Seoul, Korea)2024

Obstructive Sleep Apnea Screening and Effects of Surgery in Acromegaly: A Prospective Study.

Jaeyoung Cho, Jung Hee Kim, Yong Hwy Kim, Jinwoo Lee

Registry-linked trialAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Endocrinology and metabolism (Seoul, Korea), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03526016 (Effect of Transsphenoidal Surgery on Sleep Apnea in Patients With Acromegaly), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03526016 unknown statusnot on this map

Effect of Transsphenoidal Surgery on Sleep Apnea in Patients With Acromegaly

TypeobservationalSponsorSeoul National University HospitalRan2018 to 2021Enrolled50ConditionsSleep Apnea
3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Acromegaly complications: an update.The Journal of clinical endocrinology and metabolism · 2026
    Review
  4. Article
  5. Mechanisms associated with obstructive sleep apnea in achondroplasia.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jaeyoung ChoDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea.
Jung Hee KimDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
Yong Hwy KimPituitary Center, Seoul National University Hospital, Seoul, Korea.
Jinwoo LeeDivision of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgruoundTo identify a screening tool for obstructive sleep apnea (OSA) and evaluate the effects of endoscopic transsphenoidal surgery on improving OSA in patients with acromegaly.

methodsWe prospectively enrolled adults with acromegaly scheduled for endoscopic transsphenoidal surgery. All measurements were conducted when participants were admitted for a baseline work-up for acromegaly before surgery and surveillance approximately 3 to 6 months after surgery. Respiratory event index (REI) was used as a surrogate for apnea-hypopnea index (Trial Registration: NCT03526016).

resultsOf the 35 patients with acromegaly (median age, 47 years; 40% men; median body mass index, 24.4 kg/m2), 24 (68.6%) had OSA (REI ≥5/hour), 15 (42.9%) had moderate-to-severe OSA (REI ≥15/hour). At baseline, serum insulin-like growth factor 1 (IGF-1) levels were positively correlated with the REI (ρ=0.53, P=0.001). The sensitivity and negative predictive value of a Snoring, Tiredness, Observed apnea, high blood Pressure-Body mass index, age, Neck circumference, and Gender (STOP-Bang) score ≥ 3 were 93.3% and 87.5%, respectively, detecting moderate-to-severe OSA. Biochemical acromegaly remission was achieved in 32 (91.4%) patients. The median difference in the REI was -9.5/hour (95% confidence interval, -13.3 to -5.3). Half of the 24 patients diagnosed with OSA preoperatively had REI <5/hour postoperatively. In a linear mixed-effects model, changes in the REI across surgery were related to changes in IGF-1 levels.

conclusionThe STOP-Bang questionnaire is a reliable tool for OSA among patients with acromegaly. Improvement in OSA severity after surgery is related to decreased IGF-1 levels.

Indexed as

AcromegalyInsulin-Like Growth Factor ISleep Apnea, ObstructiveAdultEndoscopyFemaleHumansMaleMass ScreeningMiddle AgedPolysomnographyProspective StudiesTreatment OutcomeInsulin-Like Growth Factor IAcromegalyEndoscopic transsphenoidal surgeryRespiratory polygraphyScreeningSleep apnea, obstructive

Identifiers

PMID38918903
PMCPMC11375303

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.