Evidence map›Paper›PMID 38918839›Full record

ReviewJournal of nanobiotechnology2024

Phage-based delivery systems: engineering, applications, and challenges in nanomedicines.

Hui Wang, Ying Yang, Yan Xu, Yi Chen, Wenjie Zhang, Tianqing Liu, Gang Chen, Kaikai Wang

Abstract readReview
In one paragraph

Review in Journal of nanobiotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Nanoparticle-based approaches for bacterial detection and therapy.Applied microbiology and biotechnology · 2026
    Review
  8. Whole-body distribution of threeAntimicrobial agents and chemotherapy · 2026
    Article
  9. Review
  10. Review
  11. Review
  12. Review
  13. Review
  14. Article
  15. Review
  16. Article
  17. Review
  18. Dark Matter Carried byInternational journal of molecular sciences · 2025
    Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hui WangSchool of Pharmacy, Nantong University, Nantong, 226001, China.
Ying YangSchool of Pharmacy, Nantong University, Nantong, 226001, China.
Yan XuSchool of Pharmacy, Nantong University, Nantong, 226001, China.
Yi ChenSchool of Pharmacy, Nantong University, Nantong, 226001, China.
Wenjie ZhangSchool of Pharmacy, Nantong University, Nantong, 226001, China.
Tianqing LiuNICM Health Research Institute, Western Sydney University, Sydney, NSW, 2145, Australia. michelle.liu@westernsydney.edu.au.
Gang ChenQingdao Central Hospital, University of Health and Rehabilitation Sciences (Qingdao Central Medical Group), Qingdao, 266024, China. chengang@uor.edu.cn.
Kaikai WangSchool of Pharmacy, Nantong University, Nantong, 226001, China. kwang@ntu.edu.cn.

Funding

National Health and Medical Research Council 1112258
6 · The paper itself

Abstract

Bacteriophages (phages) represent a unique category of viruses with a remarkable ability to selectively infect host bacteria, characterized by their assembly from proteins and nucleic acids. Leveraging their exceptional biological properties and modifiable characteristics, phages emerge as innovative, safe, and efficient delivery vectors. The potential drawbacks associated with conventional nanocarriers in the realms of drug and gene delivery include a lack of cell-specific targeting, cytotoxicity, and diminished in vivo transfection efficiency. In contrast, engineered phages, when employed as cargo delivery vectors, hold the promise to surmount these limitations and attain enhanced delivery efficacy. This review comprehensively outlines current strategies for the engineering of phages, delineates the principal types of phages utilized as nanocarriers in drug and gene delivery, and explores the application of phage-based delivery systems in disease therapy. Additionally, an incisive analysis is provided, critically examining the challenges confronted by phage-based delivery systems within the domain of nanotechnology. The primary objective of this article is to furnish a theoretical reference that contributes to the reasoned design and development of potent phage-based delivery systems.

Indexed as

BacteriophagesDrug Delivery SystemsNanomedicineAnimalsDrug CarriersGene Transfer TechniquesHumansNanoparticlesNanotechnologyDrug CarriersDrug and gene deliveryNanocarriersPhagePhage engineeringTargeting

Identifiers

PMID38918839
PMCPMC11197292

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.