Evidence map›Paper›PMID 38918726›Full record

ArticleBMC women's health2024

Histopathologic patterns of female genital tuberculosis with clinical correlation: a 10-year (2013-2022) retrospective cross-sectional study.

Kidest Melkamu, Amanuel Damie, Senait Ashenafi, Moti Sori, Selfu Girma, Sofia Yimam, Negash Baye, Belachew Shote

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Article in BMC women's health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

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0cells of the map it votes in
7citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Kidest MelkamuDepartment of Pathology, St. Peter's Hospital, Addis Ababa, Ethiopia. kidest.m.gebeyehu@gmail.com.
Amanuel DamieDepartment of Pathology, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia. amanuel.damie@aau.edu.et.
Senait AshenafiDepartment of Pathology, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia. senashbet@gmail.com.
Moti SoriDepartment of Pathology, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
Selfu GirmaArmauer Hansen Research Institute, Addis Ababa, Ethiopia.
Sofia YimamArmauer Hansen Research Institute, Addis Ababa, Ethiopia.
Negash BayeArmauer Hansen Research Institute, Addis Ababa, Ethiopia.
Belachew ShoteDepartment of Gynecology, Wolaita Sodo University, Wolaita Sodo, Ethiopia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveUnderdiagnosis of female genital tuberculosis (FGTB) often leads to infertility. In this study, we aimed to determine the site and histopathologic patterns of FGTB and its correlation with clinical presentation and acid-fast bacilli (AFB) status.

methodsA retrospective cross-sectional study was conducted on 122 patients with a histopathological diagnosis of FGTB at the Department of Pathology, College of Health Sciences (CHS), Tikur Anbessa Specialized Hospital (TASH), Addis Ababa University (AAU), from January 1, 2013, to August 30, 2022.

resultsFemale genital tuberculosis was found in 0.94% of the gynecology specimens examined. The most common presentations were menstrual disturbance, abdominopelvic pain, and infertility. Among patients with FGTB, 4.6% exhibited misleading clinical and radiologic findings, leading to suspicion of malignancy and subsequent aggressive surgical management. The endometrium was the most frequently affected organ, followed by the fallopian tube, ovary, cervix, and vulva. In the majority of tuberculous endometritis cases (53.3%), histopathology revealed early-stage granulomas. Acid-fast bacilli were found in a significant proportion (42.6%) of FGTB tissues with TB histopathology. The ovary had the highest rate of AFB detection, followed by the fallopian tube, endometrium, and cervix.

conclusionFemale genital tuberculosis should be considered in reproductive-age women presenting with menstrual irregularities, abdominopelvic pain, infertility, or an abdominopelvic mass. The endometrium is commonly affected, displaying early granulomas with low AFB positivity.

Indexed as

Tuberculosis, Female GenitalAbdominal PainAdolescentAdultCervix UteriCross-Sectional StudiesEndometritisEndometriumEthiopiaFallopian TubesFemaleHumansInfertility, FemaleMenstruation DisturbancesMiddle AgedOvaryExtrapulmonaryFemale genitalInfertilityTuberculosis

Identifiers

PMID38918726
PMCPMC11201363

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.