Evidence map›Paper›PMID 38918662›Full record

ArticleAsian Pacific journal of cancer prevention : APJCP2024

Investigation of TLR2 (-196 to -174del) and TLR9 (T-1486C) Gene Polymorphisms Association with Inflammatory Bowel Diseases.

Roseline Eke Emele, Mohammed A Salim, Fikriye Polat, Songül Budak Diler

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Article in Asian Pacific journal of cancer prevention : APJCP, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

4 authors.

Roseline Eke EmeleDepartment of Biotechnology, Institute of Natural and Applied Sciences, University of Niğde Ömer Halisdemir, Niğde, Turkey.ORCID 0000-0001-6033-7199
Mohammed A SalimDepartment of Biotechnology, Institute of Natural and Applied Sciences, University of Niğde Ömer Halisdemir, Niğde, Turkey.ORCID 0000-0002-5897-2289
Fikriye PolatDepartment of Mathematics and Sciences Education, Faculty of Education, University of Kocaeli, Kocaeli, Turkey.ORCID 0000-0002-5414-2501
Songül Budak DilerDepartment of Biotechnology, Faculty of Science and Letters, University of Niğde Ömer Halisdemir, Niğde, Turkey.ORCID 0000-0002-7156-583X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundInflammatory bowel diseases (IBD), Crohn's disease (CD), and ulcerative colitis (UC) are diseases that result from the combined effects of a predisposing genetic background and several environmental factors, including smoking. Some genes can influence these diseases through genetic inheritance, and their regulation is explained by gene polymorphism. However, Toll-like receptor (TLR) genes have been identified as susceptibility genes for CD and UC.

methodsA case-control study was performed on a Turkish population composed of 105 healthy controls and  79 CD, 77 UC patients genotyped by Allele-specific PCR and PCR-RFLP for TLR9 (T-1486C) and TLR 2 (-196 to -174del) gene. Genotype and allele frequencies of TLR9 (T-1486C) and TLR 2 (-196 to -174del) gene polymorphisms compared to allele frequencies in CD and UC patients.

resultsNo statistically significant findings were found between the CD, UC patients, and the control group in terms of both genotype distributions and allele frequencies for TLR 9 (T-1486C; rs187084) and TLR 2 (-196 to -174del; rs111200466) gene polymorphisms in a Turkish population (P > 0.05).

conclusionNo association was found between the TLR2 (rs111200466) and TLR 9 (rs187084) gene polymorphisms among IBD patients and the control groups in the Turkish population.

Indexed as

Colitis, UlcerativeCrohn DiseaseGenetic Predisposition to DiseaseGenotypeInflammatory Bowel DiseasesToll-Like Receptor 2Toll-Like Receptor 9AdultCase-Control StudiesFemaleFollow-Up StudiesGene FrequencyHumansMaleMiddle AgedPolymorphism, Single NucleotideTLR2 protein, humanTLR9 protein, humanToll-Like Receptor 2Toll-Like Receptor 9Inflammatory Bowel DiseasesPolymorphismTLR 2 (– 196 to – 174del)TLR 9 (T-1486C)

Identifiers

PMID38918662
PMCPMC11382830

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.