ArticleNature immunology2024
A humanized mouse that mounts mature class-switched, hypermutated and neutralizing antibody responses.
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Article in Nature immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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45citing papers in PubMed
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Who cites it
45 citing papers in PubMed.
- Stepwise Evolution of Immunodeficient Mouse Models: Focus on NCG Strains and Their Applications in Humanized Immune System Research.Vaccines · 2026Review
- Pharmacokinetic and pharmacodynamic characterization of CD8-targeted lentiviral vector forMolecular therapy. Advances · 2026Article
- Insights into Microbiota-Vaccine Crosstalk in Humans: Mechanisms, Modulators, and Translational Horizons.Vaccines · 2026Review
- Establishing human immune system mice: application, opportunity, and challenges.Experimental & molecular medicine · 2026Review
- B cell TET2 recruits OGT for nuclear TET2 and H2B O-GlcNAcylation to drive AID and BLIMP-1 expression and maturation of the antibody response.Cell reports · 2026Article
- Advancement of humanized mice and leading applications in immunological disease models.Inflammation and regeneration · 2026Review
- Double humanised lupus mouse model with human immune system and faecal microbiota from patients with SLE.Lupus science & medicine · 2026Article
- Evaluation of the Effects of 50 Hz Magnetic Field Exposure on the Human Hematopoietic System in Humanized Mice.Bioelectromagnetics · 2026Article
- Recent advances in the construction of humanized animal models and applications in translational medicine.Animal models and experimental medicine · 2026Review
- A deep learning approach to assess transendothelial cell trafficking performance.Scientific reports · 2026Article
- Animal models and pathogenesis of gastric cancer: from premalignant conditions-to-metastasis.Cancer biology & medicine · 2026Review
- Humanized mice enableMolecular therapy. Advances · 2026Article
- Tumor-infiltrating B cells participate in shaping the immunosuppressive microenvironment in solid tumors.International journal of cancer · 2026Review
- Understanding the effect of estrogen on B cells: implications for immune health and autoimmunity.American journal of physiology. Cell physiology · 2026Review
- HIV-1 interactions with sialic acid-binding bacterial lectins promote virus infectivityFrontiers in cellular and infection microbiology · 2026Article
- Neonatal and pediatric thymic grafts generate similar human T-cell chimerism in humanized mice.Frontiers in immunology · 2026Article
- NeoThy™ immune-humanized mice can produce anti-drug antibodies to support immunogenicity assessment for biological drug products.Frontiers in immunology · 2026Article
- Immuno-radiotherapy enhances tumor control and induces abscopal responses in a humanized mouse model.Frontiers in immunology · 2026Article
- Development of humanized mouse models for the preclinical evaluation of NK cell-based therapies.Frontiers in immunology · 2026Article
- SCFAs' pleiotropic role in pathogenesis and salutogenesis: mechanisms in exacerbation and regulation of inflammation and fibrosis from gut to host.Journal of medical microbiology · 2026Review
Corrections and comments
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Authors and funding
8 authors.
Daniel P Chupp *The Antibody Laboratory, Department of Microbiology, Immunology & Molecular Genetics, The University of Texas Long School of Medicine, San Antonio, TX, USA.ORCID http://orcid.org/0000-0002-8930-5817
Carlos E Rivera *The Antibody Laboratory, Department of Microbiology, Immunology & Molecular Genetics, The University of Texas Long School of Medicine, San Antonio, TX, USA.ORCID http://orcid.org/0000-0001-9052-557X
Yulai Zhou *The Antibody Laboratory, Department of Microbiology, Immunology & Molecular Genetics, The University of Texas Long School of Medicine, San Antonio, TX, USA.ORCID http://orcid.org/0000-0002-1044-5148
Yijiang XuThe Antibody Laboratory, Department of Microbiology, Immunology & Molecular Genetics, The University of Texas Long School of Medicine, San Antonio, TX, USA.ORCID http://orcid.org/0000-0001-6597-1105
Patrick S RamseyDepartment of Obstetrics & Gynecology, The University of Texas Long School of Medicine, San Antonio, TX, USA.ORCID http://orcid.org/0000-0002-2613-9364
Zhenming XuThe Antibody Laboratory, Department of Microbiology, Immunology & Molecular Genetics, The University of Texas Long School of Medicine, San Antonio, TX, USA.ORCID http://orcid.org/0000-0002-5822-0570
Hong ZanThe Antibody Laboratory, Department of Microbiology, Immunology & Molecular Genetics, The University of Texas Long School of Medicine, San Antonio, TX, USA.
Paolo CasaliThe Antibody Laboratory, Department of Microbiology, Immunology & Molecular Genetics, The University of Texas Long School of Medicine, San Antonio, TX, USA. pcasali@uthscsa.edu.ORCID http://orcid.org/0000-0002-8982-5177
Funding
TISSUE CULTURE---COREP30CA054174 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Lei Zheng · 1991 to 2026
$59.1MInstitute for Integration of Medicine & Science: A Partnership to Improve HealthUL1TR002645 · NCATS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI CLARK, ROBERT A, HARGREAVES, KENNETH M · 2018 to 2022
$20.4MInstitute for Integration of Medicine & Science: A Partnership to Improve HealthUL1TR001120 · NCATS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI CLARK, ROBERT A, HARGREAVES, KENNETH M · 2013 to 2017
$16.5MSan Antonio Biomedical Education and ResearchK12GM111726 · NIGMS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI LECHLEITER, JAMES D, OYAJOBI, BABATUNDE OLUKAYODE · 2015 to 2024
$7.6MIntrinsic B cell epigenetic regulation of antibody and autoantibody responses by Sirt1R01AI105813 · NIAID · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI CASALI, PAOLO · 2014 to 2023
$4.5MSomatic hypermutation and class switching in autoimmunityR01AI079705 · NIAID · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI CASALI, PAOLO · 2010 to 2019
$4.1MEpigenetics of the autoantibody response in systemic lupusR01AI167416 · NIAID · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI CASALI, PAOLO · 2021 to 2025
$3.6MIL-27-producing B cells in the antibody responseR01AI153506 · NIAID · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI XU, ZHENMING · 2021 to 2025
$2.2MHigh Throughput DNA Sequencer: Illumina HiSeq 3000 SequencerS10OD021805 · OD · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI LAI, ZHAO · 2016 to 2016
$600kGraduate Research in Immunology Program (GRIP): To train graduate students for successful careers in academia, industry and governmentT32AI138944 · NIAID · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI ZHONG, GUANGMING · 2018 to 2022
$561kLupus Research Alliance (Lupus Research Alliance, Inc.) TIL 641363NCATS NIH HHS UL1 TR001120NCATS NIH HHS UL1 TR002645NCI NIH HHS P30 CA054174NIAID NIH HHS R01 AI079705NIAID NIH HHS R01 AI105813NIAID NIH HHS R01 AI153506NIAID NIH HHS R01 AI167416NIAID NIH HHS T32 AI138944NIGMS NIH HHS K12 GM111726NIH HHS S10 OD021805
Abstract
Humanized mice are limited in terms of modeling human immunity, particularly with regards to antibody responses. Here we constructed a humanized (THX) mouse by grafting non-γ-irradiated, genetically myeloablated Kit
Indexed as
Antibodies, NeutralizingImmunoglobulin Class SwitchingAnimalsAntibodies, ViralB-LymphocytesCell DifferentiationCOVID-19HumansMiceSARS-CoV-2Somatic Hypermutation, ImmunoglobulinAntibodies, NeutralizingAntibodies, Viral
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LicenceCC BY
Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.