Evidence map›Paper›PMID 38918576›Full record

ArticleCellular & molecular immunology2024

Targeting the intestinal circadian clock by meal timing ameliorates gastrointestinal inflammation.

Yunhui Niu, Marjolein Heddes, Baraa Altaha, Michael Birkner, Karin Kleigrewe, Chen Meng, Dirk Haller, Silke Kiessling

Abstract read
In one paragraph

Article in Cellular & molecular immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yunhui NiuZIEL - Institute for Food & Health, Technical University of Munich, 85354, Freising, Germany.
Marjolein HeddesZIEL - Institute for Food & Health, Technical University of Munich, 85354, Freising, Germany.
Baraa AltahaZIEL - Institute for Food & Health, Technical University of Munich, 85354, Freising, Germany.
Michael BirknerChair of Nutrition and Immunology, School of Life Sciences, Technical University of Munich, Gregor-Mendel-Str. 2, 85354, Freising, Germany.
Karin KleigreweBavarian Center for Biomolecular Mass Spectrometry, Technical University of Munich, Gregor-Mendel-Str. 4, 85354, Freising, Germany.
Chen MengBavarian Center for Biomolecular Mass Spectrometry, Technical University of Munich, Gregor-Mendel-Str. 4, 85354, Freising, Germany.
Dirk HallerZIEL - Institute for Food & Health, Technical University of Munich, 85354, Freising, Germany.ORCID 0000-0002-6977-4085
Silke KiesslingZIEL - Institute for Food & Health, Technical University of Munich, 85354, Freising, Germany. s.kiessling@surrey.ac.uk.

Funding

Deutsche Forschungsgemeinschaft (German Research Foundation) 395357507 - SFB 1371
6 · The paper itself

Abstract

The expression of clock genes has been observed to be impaired in biopsies from patients with inflammatory bowel disease (IBD). Disruption of circadian rhythms, which occurs in shift workers, has been linked to an increased risk of gastrointestinal diseases, including IBD. The peripheral circadian clock in intestinal epithelial cells (IECs) was previously shown to balance gastrointestinal homeostasis by regulating the microbiome. Here, we demonstrated that the intestinal clock is disrupted in an IBD-relevant mouse model (IL-10

Indexed as

ARNTL Transcription FactorsCircadian ClocksColitisInterleukin-10Mice, KnockoutAnimalsCircadian RhythmDisease Models, AnimalGastrointestinal MicrobiomeInflammationInflammatory Bowel DiseasesIntestinal MucosaIntestinesMiceMice, Inbred C57BLARNTL Transcription FactorsBmal1 protein, mouseInterleukin-10Gastrointestinal inflammationIBDIntestinal circadian clockMicrobiotaRestricted feeding

Identifiers

PMID38918576
PMCPMC11291886

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.