Evidence map›Paper›PMID 38918539›Full record

ArticleScientific reports2024

New hemisynthetic derivatives of sphaeropsidin phytotoxins triggering severe endoplasmic reticulum swelling in cancer cells.

Aude Ingels, Robert Scott, Annie R Hooper, Aletta E van der Westhuyzen, Sachin B Wagh, Joséphine de Meester, Lucia Maddau, Doris Marko, Georg Aichinger, Walter Berger and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Aude Ingels *Department of Pharmacotherapy and Pharmaceutics, Chemistry and Biochemistry, Faculté de Pharmacie, Université Libre de Bruxelles, Brussels, Belgium.
Robert Scott *Department of Chemistry and Biochemistry, Texas State University, San Marcos, TX, 78666, USA.
Annie R Hooper *Department of Chemistry and Biochemistry, Texas State University, San Marcos, TX, 78666, USA.
Aletta E van der WesthuyzenDepartment of Chemistry and Polymer Science, University of Stellenbosch, Matieland, Stellenbosch, 7600, South Africa.
Sachin B WaghDepartment of Chemistry and Biochemistry, Texas State University, San Marcos, TX, 78666, USA.
Joséphine de MeesterDepartment of Chemistry and Polymer Science, University of Stellenbosch, Matieland, Stellenbosch, 7600, South Africa.
Lucia MaddauDepartment of Agriculture, Section of Plant Pathology and Entomology, University of Sassari, Sassari, Italy.
Doris MarkoDepartment of Food Chemistry and Toxicology, Faculty of Chemistry, University of Vienna, Vienna, Austria.
Georg AichingerDepartment of Food Chemistry and Toxicology, Faculty of Chemistry, University of Vienna, Vienna, Austria.
Walter BergerMedical University of Vienna Center for Cancer Research, Vienna, Austria.
Marjorie VermeerschElectron Microscopy Laboratory, Center for Microscopy and Molecular Imaging (CMMI), Université Libre de Bruxelles (ULB), Gosselies, Belgium.
David Pérez-MorgaElectron Microscopy Laboratory, Center for Microscopy and Molecular Imaging (CMMI), Université Libre de Bruxelles (ULB), Gosselies, Belgium.
Vladimir A MaslivetcDepartment of Chemistry and Biochemistry, Texas State University, San Marcos, TX, 78666, USA.
Antonio EvidenteInstitute of Biomolecular Chemistry, National Research Council, Pozzuoli, Italy.
Willem A L van OtterloDepartment of Chemistry and Polymer Science, University of Stellenbosch, Matieland, Stellenbosch, 7600, South Africa.
Alexander KornienkoDepartment of Chemistry and Biochemistry, Texas State University, San Marcos, TX, 78666, USA. a_k76@txstate.edu.
Véronique MathieuDepartment of Pharmacotherapy and Pharmaceutics, Chemistry and Biochemistry, Faculté de Pharmacie, Université Libre de Bruxelles, Brussels, Belgium. veronique.mathieu@ulb.be.

Funding

Acid-Sensitive Glioblastoma Prodrugs Derived from Ophiobolin AR15CA227680 · NCI · TEXAS STATE UNIVERSITY · PI KORNIENKO, ALEXANDER · 2019 to 2019
$462k
Tandem Discovery of Drug Leads and Targets via Paal-Knorr reactionR21GM131717 · NIGMS · TEXAS STATE UNIVERSITY · PI KORNIENKO, ALEXANDER, LA CLAIR, JAMES J · 2019 to 2020
$374k
Foundation for the National Institutes of Health GM131717-01National Research Foundation UID 113322NCI NIH HHS R15 CA227680NIGMS NIH HHS R21 GM131717
6 · The paper itself

Abstract

Sphaeropsidins are iso-pimarane diterpenes produced by phytopathogenic fungi that display promising anticancer activities. Sphaeropsidin A, in particular, has been shown to counteract regulatory volume increase, a process used by cancer cells to avoid apoptosis. This study reports the hemi-synthesis of new lipophilic derivatives obtained by modifications of the C15,C16-alkene moiety. Several of these compounds triggered severe ER swelling associated with strong proteasomal inhibition and consequently cell death, a feature that was not observed with respect to mode of action of the natural product. Significantly, an analysis from the National Cancer Institute sixty cell line testing did not reveal any correlations between the most potent derivative and any other compound in the database, except at high concentrations (LC

Indexed as

Endoplasmic ReticulumAbietanesAntineoplastic AgentsApoptosisCell Line, TumorDiterpenesHumansAbietanesAntineoplastic AgentsDiterpenesCancerDiterpeneEndoplasmic reticulum swellingER stressIso-pimaraneNatural productSphaeropsidin

Identifiers

PMID38918539
PMCPMC11199504

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.