Evidence map›Paper›PMID 38918517›Full record

ArticleNature human behaviour2024

Short- and long-term neuropsychiatric outcomes in long COVID in South Korea and Japan.

Sunyoung Kim, Hayeon Lee, Jinseok Lee, Seung Won Lee, Rosie Kwon, Min Seo Kim, Ai Koyanagi, Lee Smith, Guillaume Fond, Laurent Boyer and 13 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature human behaviour, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  4. Herpes zoster vaccination and cognitive disorders in older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Sunyoung Kim *Department of Family Medicine, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, South Korea.
Hayeon Lee *Department of Biomedical Engineering, Kyung Hee University, Yongin, South Korea. wwhy28@khu.ac.kr.ORCID http://orcid.org/0009-0000-2403-6241
Jinseok LeeDepartment of Biomedical Engineering, Kyung Hee University, Yongin, South Korea.ORCID http://orcid.org/0000-0002-8580-490X
Seung Won LeeDepartment of Precision Medicine, Sungkyunkwan University School of Medicine, Suwon, South Korea.ORCID http://orcid.org/0000-0001-5632-5208
Rosie KwonCenter for Digital Health, Medical Science Research Institute, Kyung Hee University College of Medicine, Seoul, South Korea.
Min Seo KimCardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0003-2115-7835
Ai KoyanagiResearch and Development Unit, Parc Sanitari Sant Joan de Deu, Barcelona, Spain.
Lee SmithCentre for Health, Performance and Wellbeing, Anglia Ruskin University, Cambridge, UK.ORCID http://orcid.org/0000-0002-5340-9833
Guillaume FondResearch Centre on Health Services and Quality of Life, Assistance Publique-Hôpitaux de Marseille, Aix Marseille University, Marseille, France.ORCID http://orcid.org/0000-0003-3249-2030
Laurent BoyerResearch Centre on Health Services and Quality of Life, Assistance Publique-Hôpitaux de Marseille, Aix Marseille University, Marseille, France.
Masoud RahmatiResearch Centre on Health Services and Quality of Life, Assistance Publique-Hôpitaux de Marseille, Aix Marseille University, Marseille, France.ORCID http://orcid.org/0000-0003-4792-027X
Guillermo F López SánchezDivision of Preventive Medicine and Public Health, Department of Public Health Sciences, School of Medicine, University of Murcia, Murcia, Spain.ORCID http://orcid.org/0000-0002-9897-5273
Elena DragiotiPain and Rehabilitation Centre, and Department of Medical and Health Sciences, Linköping University, Linköping, Sweden.
Samuele CorteseCentre for Innovation in Mental Health, School of Psychology, Faculty of Environmental and Life Sciences, University of Southampton, Southampton, UK.
Ju-Young ShinSchool of Pharmacy, Sungkyunkwan University, Suwon, South Korea.
Ahhyung ChoiSchool of Pharmacy, Sungkyunkwan University, Suwon, South Korea.
Hae Sun SuhDepartment of Regulatory Science, Kyung Hee University Graduate School, Seoul, South Korea.
Sunmi LeeDepartment of Applied Mathematics, Kyung Hee University, Yongin, South Korea.
Marco SolmiDepartment of Psychiatry, SCIENCES lab, University of Ottawa, Ottawa, Ontario, Canada.ORCID http://orcid.org/0000-0003-4877-7233
Chanyang MinCenter for Digital Health, Medical Science Research Institute, Kyung Hee University College of Medicine, Seoul, South Korea.
Jae Il ShinDepartment of Pediatrics, Yonsei University College of Medicine, Seoul, South Korea. SHINJI@yuhs.ac.ORCID http://orcid.org/0000-0003-2326-1820
Dong Keon YonCenter for Digital Health, Medical Science Research Institute, Kyung Hee University College of Medicine, Seoul, South Korea. yonkkang@gmail.com.ORCID http://orcid.org/0000-0003-1628-9948
Paolo Fusar-PoliEarly Psychosis: Interventions and Clinical-Detection Lab, Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.

Funding

Korea Health Industry Development Institute (KHIDI) HI22C1976Ministry of Food and Drug Safety (MFDS) 21153MFDS601National Research Foundation of Korea (NRF) RS-2023-00248157
6 · The paper itself

Abstract

We investigated whether SARS-CoV-2 infection is associated with short- and long-term neuropsychiatric sequelae. We used population-based cohorts from the Korean nationwide cohort (discovery; n = 10,027,506) and the Japanese claims-based cohort (validation; n = 12,218,680) to estimate the short-term (<30 days) and long-term (≥30 days) risks of neuropsychiatric outcomes after SARS-CoV-2 infection compared with general population groups or external comparators (people with another respiratory infection). Using exposure-driven propensity score matching, we found that both the short- and long-term risks of developing neuropsychiatric sequelae were elevated in the discovery cohort compared with the general population and those with another respiratory infection. A range of conditions including Guillain-Barré syndrome, cognitive deficit, insomnia, anxiety disorder, encephalitis, ischaemic stroke and mood disorder exhibited a pronounced increase in long-term risk. Factors such as mild severity of COVID-19, increased vaccination against COVID-19 and heterologous vaccination were associated with reduced long-term risk of adverse neuropsychiatric outcomes. The time attenuation effect was the strongest during the first six months after SARS-CoV-2 infection, and this risk remained statistically significant for up to one year in Korea but beyond one year in Japan. The associations observed were replicated in the validation cohort. Our findings contribute to the growing evidence base on long COVID by considering ethnic diversity.

Indexed as

COVID-19AdultAgedCohort StudiesFemaleHumansJapanMaleMental DisordersMiddle AgedRepublic of KoreaRisk FactorsSARS-CoV-2

Identifiers

PMID38918517

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.