Evidence map›Paper›PMID 38918456›Full record

ArticleScientific reports2024

Manufacturing and preclinical toxicity of GLP grade gene deleted attenuated Leishmania donovani parasite vaccine.

Kumar Avishek, Mirza A Beg, Kavita Vats, Avinash Kumar Singh, Ranadhir Dey, Kamaleshwar P Singh, Rajesh Kumar Singh, Sreenivas Gannavaram, V Ramesh, Mohmad Sadik A Mulla and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. An update on recombinant vaccines against leishmaniasis.The Indian journal of medical research · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Kumar Avishek *ICMR-National Institute of Pathology, Safdarjung Hospital Campus, New Delhi, 110029, India.
Mirza A Beg *Department of Molecular Medicine, Jamia Hamdard, New Delhi, 110062, India.
Kavita Vats *Department of Molecular Medicine, Jamia Hamdard, New Delhi, 110062, India.
Avinash Kumar Singh *Gennova Biopharmaceuticals, Hinjewadi Phase II, Pune, Maharashtra, 411057, India.
Ranadhir DeyDivision of Emerging and Transfusion Transmitted Diseases, CBER, Food and Drug Administration, Silver Spring, MD, 20993, USA.
Kamaleshwar P SinghGennova Biopharmaceuticals, Hinjewadi Phase II, Pune, Maharashtra, 411057, India.
Rajesh Kumar SinghGennova Biopharmaceuticals, Hinjewadi Phase II, Pune, Maharashtra, 411057, India.
Sreenivas GannavaramDivision of Emerging and Transfusion Transmitted Diseases, CBER, Food and Drug Administration, Silver Spring, MD, 20993, USA.
V RameshDepartment of Dermatology and STD, ESIC Medical College, Faridabad, Haryana, 121001, India.
Mohmad Sadik A MullaVimta Laboratories, Cherlapally, Hyderabad, Telangana, 500051, India.
Upendra BhatnagarVimta Laboratories, Cherlapally, Hyderabad, Telangana, 500051, India.
Sanjay SinghGennova Biopharmaceuticals, Hinjewadi Phase II, Pune, Maharashtra, 411057, India.
Hira L NakhasiDivision of Emerging and Transfusion Transmitted Diseases, CBER, Food and Drug Administration, Silver Spring, MD, 20993, USA.
Poonam SalotraICMR-National Institute of Pathology, Safdarjung Hospital Campus, New Delhi, 110029, India.
Angamuthu SelvapandiyanDepartment of Molecular Medicine, Jamia Hamdard, New Delhi, 110062, India. selvapandiyan@jamiahamdard.ac.in.

Funding

Biotechnology Industry Research Assistance Council, India BT/CRS02l 4/CRS-1 0/l 6
6 · The paper itself

Abstract

Centrin1 gene deleted Leishmania donovani parasite (LdCen1

Indexed as

Gene DeletionLeishmania donovaniLeishmaniasis, VisceralVaccines, AttenuatedAnimalsCricetinaeDogsFemaleHumansLeishmaniasis VaccinesLeukocytes, MononuclearProtozoan ProteinsLeishmaniasis VaccinesProtozoan ProteinsVaccines, AttenuatedLeishmania donovaniLive attenuatedPreclinicalToxicity studyVaccine candidateVisceral leishmaniasis

Identifiers

PMID38918456
PMCPMC11199483

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.