Evidence map›Paper›PMID 38918446›Full record

Observational studyScientific reports2024

Fetal cord plasma herpesviruses and preeclampsia: an observational cohort study.

Inka Häkkinen, Gamze Yazgeldi Gunaydin, Lari Pyöriä, Shohei Kojima, Nicholas Parrish, Maria F Perdomo, Juho Wedenoja, Klaus Hedman, Seppo Heinonen, Eero Kajantie and 4 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Observational
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Inka HäkkinenStem Cells and Metabolism Research Program, University of Helsinki, Helsinki, Finland.
Gamze Yazgeldi GunaydinStem Cells and Metabolism Research Program, University of Helsinki, Helsinki, Finland.
Lari PyöriäDepartment of Virology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Shohei KojimaGenome Immunobiology RIKEN Hakubi Research Team, RIKEN Center for Integrative Medical Sciences and RIKEN Cluster for Pioneering Research, Yokohama, Japan.
Nicholas ParrishGenome Immunobiology RIKEN Hakubi Research Team, RIKEN Center for Integrative Medical Sciences and RIKEN Cluster for Pioneering Research, Yokohama, Japan.
Maria F PerdomoDepartment of Virology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Juho WedenojaDepartment of Ophthalmology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Klaus HedmanDepartment of Virology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Seppo HeinonenObstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Eero KajantiePublic Health Promotion Unit, Finnish Institute for Health and Welfare, Helsinki and Oulu, Finland.
Hannele LaivuoriDepartment of Obstetrics and Gynecology, Tampere University Hospital, Wellbeing Services County of Pirkanmaa, Tampere, Finland.
Juha KereFolkhälsan Research Center, Helsinki, Finland.
Shintaro KatayamaStem Cells and Metabolism Research Program, University of Helsinki, Helsinki, Finland.
Satu WedenojaObstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland. satu.wedenoja@helsinki.fi.

Funding

Academy of Finland 121196, 134957 and 278941Knut och Alice Wallenbergs Stiftelse KAW 2015.0096
6 · The paper itself

Abstract

A previous study suggested that fetal inheritance of chromosomally integrated human herpesvirus 6 (ici-HHV6) is associated with the hypertensive pregnancy disorder preeclampsia (PE). We aimed to study this question utilizing cord plasma samples (n = 1276) of the Finnish Genetics of Preeclampsia Consortium (FINNPEC) cohort: 539 from a pregnancy with PE and 737 without. We studied these samples and 30 placentas from PE pregnancies by a multiplex qPCR for the DNAs of all nine human herpesviruses. To assess the population prevalence of iciHHV-6, we studied whole-genome sequencing data from blood-derived DNA of 3421 biobank subjects. Any herpes viral DNA was detected in only two (0.37%) PE and one (0.14%) control sample (OR 2.74, 95% CI 0.25-30.4). One PE sample contained iciHHV-6B and another HHV-7 DNA. The control's DNA was of iciHHV-6B; the fetus having growth restriction and preterm birth without PE diagnosis. Placentas showed no herpesviruses. In the biobank data, 3 of 3421 subjects (0.08%) had low level HHV-6B but no iciHHV-6. While iciHHV-6 proved extremely rare, both fetuses with iciHHV-6B were growth-restricted, preterm, and from a pregnancy with maternal hypertension. Our findings suggest that human herpesviruses are not a significant cause of PE, whereas iciHHV-6 may pose some fetal risk.

Indexed as

Herpesvirus 6, HumanPre-EclampsiaAdultCohort StudiesDNA, ViralFemaleFetal BloodFinlandHerpesviridaeHumansPlacentaPregnancyDNA, ViralBiobankCord plasmaDNAHerpesvirusPreeclampsia

Identifiers

PMID38918446
PMCPMC11199493

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.