ArticleNature communications2024
Shape of the first mitotic spindles impacts multinucleation in human embryos.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Power-law scaling of mitotic spindles with genome sizes across eukaryotes is driven by chromosome crowding.Nature cell biology · 2026Article
- First cleavage signatures define a temporal trade-off and predict embryo fitness.Scientific reports · 2026Article
- From Static to Dynamic: Fluorescence Imaging Technology Advances Precise Embryo Evaluation.Small methods · 2026Review
- Long-term imaging of cell divisions in human preimplantation embryos.Nature biotechnology · 2026Article
- PMEnvironment & health (Washington, D.C.) · 2026Article
- Article
- Alignment among the zygotic cleavage plane, pronuclear axis, and polar axis predicts live birth outcome of blastocyst.Journal of assisted reproduction and genetics · 2026Article
- Nuclear error phenotypes at the first mitosis predict cleavage-stage outcomes but not blastocyst competence.Frontiers in reproductive health · 2026Article
- Capturing aberrant cell behaviors producing defects in human embryos via live imaging.Science advances · 2025Article
- The Drosophila nucleoporin ELYS is required for parental chromosome arrangement at fertilization.G3 (Bethesda, Md.) · 2025Article
- Embryonic Outcomes, Live-Birth Outcomes After Embryo Transfer, and Euploid Rates for Various Direct Cleavage Timing Definitions During First Cytokinesis: A Single-Center, Large-Cohort, Retrospective Study.Reproductive sciences (Thousand Oaks, Calif.) · 2025Article
- Spermatozoa centriole quality determined by FRAC may correlate with zygote nucleoli polarization-a pilot study.Journal of assisted reproduction and genetics · 2025Article
- Transcriptional insights on the incomplete cytoplasmic maturation and developmental potential of oocytes cultured without granulosa cells in mice.BMC genomics · 2025Article
- Nuclear error phenotypes in the two-cell embryo are correlated to blastocyst formation rate after assisted reproduction.Journal of assisted reproduction and genetics · 2025Article
- On the origin of mitosis-derived human embryo aneuploidy.Nature communications · 2024Article
- High proportion of zygotes with multiple pronuclei increase the embryo multinucleation rate during conventional IVF.Scientific reports · 2024Article
- Zygotic spindle orientation defines cleavage pattern and nuclear status of human embryos.Nature communications · 2024Article
- Multinucleation in the Human Embryo's First Mitosis: Linking Spindle Geometry Defects, SAC Tolerance, Chromosome Segregation, and Nuclear Envelope Reassembly.Reproductive medicine and biologyReview
Corrections and comments
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Authors and funding
17 authors.
Funding
Abstract
During human embryonic development, early cleavage-stage embryos are more susceptible to errors. Studies have shown that many problems occur during the first mitosis, such as direct cleavage, chromosome segregation errors, and multinucleation. However, the mechanisms whereby these errors occur during the first mitosis in human embryos remain unknown. To clarify this aspect, in the present study, we image discarded living human two-pronuclear stage zygotes using fluorescent labeling and confocal microscopy without microinjection of DNA or mRNA and investigate the association between spindle shape and nuclear abnormality during the first mitosis. We observe that the first mitotic spindles vary, and low-aspect-ratio-shaped spindles tend to lead to the formation of multiple nuclei at the 2-cell stage. Moreover, we observe defocusing poles in many of the first mitotic spindles, which are strongly associated with multinucleation. Additionally, we show that differences in the positions of the centrosomes cause spindle abnormality in the first mitosis. Furthermore, many multinuclei are modified to form mononuclei after the second mitosis because the occurrence of pole defocusing is firmly reduced. Our study will contribute markedly to research on the occurrence of mitotic errors during the early cleavage of human embryos.
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