Evidence map›Paper›PMID 38918381›Full record

ArticleNature communications2024

Dissecting heritability, environmental risk, and air pollution causal effects using > 50 million individuals in MarketScan.

Daniel McGuire, Havell Markus, Lina Yang, Jingyu Xu, Austin Montgomery, Arthur Berg, Qunhua Li, Laura Carrel, Dajiang J Liu, Bibo Jiang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Injectable natural hydrogel-loaded TaCommunications chemistry · 2026
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Daniel McGuire *Department of Public Health Sciences, Penn State College of Medicine, Hershey, PA, 17033, USA.
Havell Markus *MD/PhD Program, Penn State College of Medicine of Medicine, Hershey, PA, 17033, USA.
Lina YangDepartment of Public Health Sciences, Penn State College of Medicine, Hershey, PA, 17033, USA.
Jingyu XuDepartment of Public Health Sciences, Penn State College of Medicine, Hershey, PA, 17033, USA.
Austin MontgomeryMD/PhD Program, Penn State College of Medicine of Medicine, Hershey, PA, 17033, USA.
Arthur BergDepartment of Public Health Sciences, Penn State College of Medicine, Hershey, PA, 17033, USA.
Qunhua LiDepartment of Statistics, Penn State University, University Park, PA, USA.ORCID http://orcid.org/0000-0003-0675-7648
Laura CarrelDepartment of Biochemistry and Molecular Biology, Penn State College of Medicine, Hershey, PA, 17033, USA.ORCID http://orcid.org/0000-0002-5868-4228
Dajiang J LiuDepartment of Public Health Sciences, Penn State College of Medicine, Hershey, PA, 17033, USA. dajiang.liu@psu.edu.ORCID http://orcid.org/0000-0001-6553-858X
Bibo JiangDepartment of Public Health Sciences, Penn State College of Medicine, Hershey, PA, 17033, USA. bjiang@phs.psu.edu.ORCID http://orcid.org/0000-0001-8336-9302

Funding

Methods to unveil sex-specific genetic architecture in trans-ancestry meta-analysisR01HG011035 · NHGRI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI Bibo Jiang · 2022 to 2026
$3.8M
Integrative approaches to understand systemic lupus erythematosus etiology in trans-ancestry genetic studiesR01AI174108 · NIAID · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI Laura Carrel, Dajiang Liu · 2022 to 2026
$2.8M
Computation, Bioinformatics, and Statistics (CBIOS) Training ProgramT32GM102057 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI CHIAROMONTE, FRANCESCA, GIRIRAJAN, SANTHOSH · 2013 to 2022
$2.7M
Statistical methods for improving reproducibility and utility of sequencing dataR01GM109453 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI LI, QUNHUA · 2013 to 2022
$2.3M
Integrative genomic and geospatial analysis of insurance claim, biobank and GWAS summary statistics for complex traitsR01ES036042 · NIEHS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI Bibo Jiang · 2023 to 2026
$2.1M
Multi-omic Characterization of COPD in FemalesR01HL173869 · NHLBI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI Dajiang Liu, ANI Wang MANICHAIKUL · 2024 to 2026
$1.7M
Methods and tools to integrate multi-omics datasets to understand preclinical autoimmune and immune-mediated diseasesU01AI185638 · NIAID · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI Dajiang Liu · 2024 to 2026
$1.3M
Methods to maximize the utility of common fund functional genomic data in multi-ethnic genetic studiesR03OD032630 · OD · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI LIU, DAJIANG · 2021 to 2021
$335k
Genetic regulation of genes on active and inactive X chromosome and their contribution to sex-biased diseasesF30GM151848 · NIGMS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI MARKUS, HAVELL · 2023 to 2024
$69k
NHGRI NIH HHS R01 HG011035NHLBI NIH HHS R01 HL173869NIAID NIH HHS R01 AI174108NIAID NIH HHS U01 AI185638NIEHS NIH HHS R01 ES036042NIGMS NIH HHS F30 GM151848NIGMS NIH HHS R01 GM109453NIGMS NIH HHS T32 GM102057NIH HHS R03 OD032630
6 · The paper itself

Abstract

Large national-level electronic health record (EHR) datasets offer new opportunities for disentangling the role of genes and environment through deep phenotype information and approximate pedigree structures. Here we use the approximate geographical locations of patients as a proxy for spatially correlated community-level environmental risk factors. We develop a spatial mixed linear effect (SMILE) model that incorporates both genetics and environmental contribution. We extract EHR and geographical locations from 257,620 nuclear families and compile 1083 disease outcome measurements from the MarketScan dataset. We augment the EHR with publicly available environmental data, including levels of particulate matter 2.5 (PM

Indexed as

Air PollutionNitrogen DioxideParticulate MatterAdultAir PollutantsElectronic Health RecordsEnvironmental ExposureFemaleGene-Environment InteractionGenetic Predisposition to DiseaseHumansMaleMiddle AgedRisk FactorsAir PollutantsNitrogen DioxideParticulate Matter

Identifiers

PMID38918381
PMCPMC11199552

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.