Evidence map›Paper›PMID 38918375›Full record

ArticleNature communications2024

N-terminal cysteine acetylation and oxidation patterns may define protein stability.

Karen C Heathcote, Thomas P Keeley, Matti Myllykoski, Malin Lundekvam, Nina McTiernan, Salma Akter, Norma Masson, Peter J Ratcliffe, Thomas Arnesen, Emily Flashman

Abstract read
In one paragraph

Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. An Enigma of N-termini dependent protein degradation.Biochemistry and biophysics reports · 2025
    Article
  6. Review
  7. Nitric oxide promotes cysteine N-degron proteolysis through control of oxygen availability.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  8. Global profiling of N-terminal cysteine-dependent degradation mechanisms.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  9. Article
  10. Oxygen sensing and plant adaptation to flooding in a changing climate.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Karen C HeathcoteDepartment of Chemistry, University of Oxford, OX1 3TA, Oxford, UK.ORCID http://orcid.org/0000-0002-6909-0118
Thomas P KeeleyLudwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, OX3 7FZ, Oxford, UK.
Matti MyllykoskiDepartment of Biomedicine, University of Bergen, 5020, Bergen, Norway.ORCID http://orcid.org/0000-0001-6641-5856
Malin LundekvamDepartment of Biomedicine, University of Bergen, 5020, Bergen, Norway.
Nina McTiernanDepartment of Biomedicine, University of Bergen, 5020, Bergen, Norway.ORCID http://orcid.org/0000-0002-1749-6933
Salma AkterDepartment of Chemistry, University of Oxford, OX1 3TA, Oxford, UK.
Norma MassonLudwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, OX3 7FZ, Oxford, UK.
Peter J RatcliffeLudwig Institute for Cancer Research, Nuffield Department of Medicine, University of Oxford, OX3 7FZ, Oxford, UK. peter.ratcliffe@ndm.ox.ac.uk.ORCID http://orcid.org/0000-0002-2853-806X
Thomas ArnesenDepartment of Biomedicine, University of Bergen, 5020, Bergen, Norway. thomas.arnesen@uib.no.ORCID http://orcid.org/0000-0002-3005-147X
Emily FlashmanDepartment of Biology, University of Oxford, OX1 3RB, Oxford, UK. emily.flashman@biology.ox.ac.uk.ORCID http://orcid.org/0000-0002-4169-4278

Funding

EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council) 864888Wellcome Trust
6 · The paper itself

Abstract

Oxygen homeostasis is maintained in plants and animals by O

Indexed as

CysteineOxidation-ReductionProtein StabilityAcetylationAmino Acid SequenceHEK293 CellsHumansOxygenProtein Processing, Post-TranslationalCysteineOxygen

Identifiers

PMID38918375
PMCPMC11199558

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.